Sexual Minority Stress Experiences Among LGBTQ Youth
Conditions
Brief summary
The goal of this R21 grant is to test the feasibility of a theoretically informed, LGBTQ-affirming intervention (Proud & Empowered; P&E). Although LGBTQ adolescents experience disparities in behavioral health outcomes compared to their heterosexual peers, interventions are scarce. For example, LGBTQ adolescents are 3 to 4 times more likely to meet criteria for an internalizing disorder and 2 to 5 times more likely to meet criteria for externalizing disorders than their heterosexual peers. Our intervention seeks to address disparate behavioral health problems such as depression, anxiety and trauma symptomology. Our goal will be achieved by completing two specific aims: 1) Assess the feasibility, including recruitment, enrollment, fidelity of service delivery, satisfaction, safety, and retention, of the intervention in a randomized control trial with four schools, 2) Obtain preliminary estimates of intervention effects on key behavioral health symptoms for LGBTQ youth and school climate (norms, attitudes, beliefs, behaviors) at the school level in preparation for a larger efficacy trial. This innovative R21 application brings together a team of nationally recognized minority stress and prevention science experts and responds to a nationally established public health need for research from the Institute of Medicine, the National Institutes of Health, and the National Gay and Lesbian Task Force.
Interventions
Proud & Empowered! is a school-based intervention to decrease sexual minority stress and improve coping among LGBTQ students. It is administered by school counselors and trained social workers.
Sponsors
Study design
Eligibility
Inclusion criteria
* LGBTQ student in one of four high schools
Exclusion criteria
* Not meeting inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PTSD Checklist for DSM-5 (PCL-5) | Change between baseline and post-intervention/follow-up (12 weeks). | 20-item self-report assessment of post-traumatic stress disorder (PTSD) symptoms which addresses all 20 DSM-5 symptoms of PTSD. A total symptom severity score can be calculated by summing the scores for each of the 20 items. Each item has five possible responses including Not at all which is scored as a 0, A little bit which is scored as a 1, Moderately which is scored as 2, Quite a bit which is scored as a 3, and Extremely which is scored as a 4. The potential range of scores is 0-80. Higher scores indicate a worse outcome where the individual has higher severity of PTSD symptoms. |
| Sexual Minority Adolescent Stress Inventory (SMASI) | Change between baseline and post-intervention/follow-up (12 weeks). | 54-item survey across 10 domains of minority stress. Assesses experiences of minority stress among adolescents. Each statement reflects past-30-day thoughts, feelings, and situations a person may have experienced, with response options of 1 = yes and 0 = no. A total score was calculated by summing the 54 items. The total score ranged from 0-54. Higher values correspond to a worse outcome, meaning the individual in question has had more stressful experiences. |
| Beck Anxiety Inventory (BAI) | Change between baseline and post-intervention/follow-up (12 weeks). | 21-item self-report assessment of anxiety symptoms. The total score is calculated by taking the sum of the 21 items. There are five responses an individual can choose from for each item, these being Not at all which is scored as a 1, Mildly, but it didn't bother me much which is scored as a 2, Moderately -- It wasn't pleasant at times which is scored as a 3, Severely -- It bothered me a lot which is scored as a 4, and Decline to answer which is scored as a 5. The total score ranges from 0-63. Higher values indicate higher self-reported anxiety: Score of 0-21 indicates low anxiety, Score of 22-35 indicates moderate anxiety, Scores of 36+ indicates potentially concerning levels of anxiety. Subscales are calculated through summation. |
| Adapted CSSRS Suicide Questions (Columbia Suicide Severity Rating Scale) | Change between baseline and post-intervention/follow-up (12 weeks). | Six items assessing current suicidality that were adapted from the longer, treatment-based Columbia Suicide Severity Rating Scale. The first two items ask about passive ideation and active ideation, and affirmative responses link to follow-up questions about methods, intent, plans, and attempts. The scale is scored as follows: 0 = no to passive ideation and no to active ideation 1. = yes to passive ideation (but no to active ideation) 2. = yes to active ideation (but no method, intent, plan) 3. = yes to method (but no intent or plan) 4. = yes to intent (but no plan) 5. = yes to plan Attempts can be scored on its own or added to the overall scale for a risk score of 6 if participant has a recent suicide attempt. |
| Beck Depression Inventory | Change between baseline and post-intervention/follow-up (12 weeks). | 21-item self-report assessment of depression symptoms and severity of depression. The items are rated on a 4-point scale ranging from 0-3 based on the severity of each item (e.g., 0=I do not feel sad, 1=I feel sad much of the time, 2=I am sad all the time, and 3=I am so sad or unhappy that I can't stand it). The total range of scores is from 0-63. Higher values indicate a worse outcome and indicates a greater severity of depression. Scores of 0-13 indicates minimal depression, scores of 14-19 indicates mild depression, scores of 20-28 indicates moderate depression, scores of 29-63 indicates severe depression. Subscale values are achieved through summation. |
| Coping Strategies Inventory | Change between baseline and post-intervention/follow-up (12 weeks). | 16-item assessment measuring specific coping strategies people use in response to stressful events. Individuals respond to 16 items, with each item assessing components of Problem Solving, Cognitive Restructuring, Social Support, Express Emotions, Problem Avoidance, Wishful Thinking, and Social Withdrawal. Individuals can respond in 5 different ways, these being Never, Seldom, Sometimes, Often, or Almost Always. These responses are scored from 1-5 with Never being a 1 and Almost Always being a 5. The total score is a summation of item scores with a range from 16-80. Higher scores in a particular primary scale indicates that the individual implements that form of coping strategy more often. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Youth Risk Behavior Survey Substance Use Questions | Change between baseline and post-intervention/follow-up (12 weeks). | Measures individual's usage of various substances in their lifetime and within the past 30 days as well as the ways in which individuals have used marijuana, tobacco, or nicotine in the past 30 days. Each substance is individually analyzed for both lifetime usage and past 30 day usage. Individuals can answer Yes or No for both lifetime usage and past 30 day usage. Each substance can range from 0 to the maximum number of survey responses. In addition, for marijuana, students can specify the way in which they used it with response options of smoking, vaping, edible or beverage form, or other. For nicotine and tobacco, students can specify the way in which they used it with the response options of smoking, vaping, or other. Yes responses indicate a worse outcome indicating that individuals have used or are currently using the substance in question. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Intervention Schools Schools will be assigned to either intervention or control schools. Students in intervention schools will receive the intervention in semester 1.
Proud & Empowered!: Proud & Empowered! is a school-based intervention to decrease sexual minority stress and improve coping among LGBTQ students. It is administered by school counselors and trained social workers. | 26 |
| Control Schools Students in control schools will receive no intervention. | 18 |
| Total | 44 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Lost to Follow-up | 1 | 2 |
Baseline characteristics
| Characteristic | Intervention Schools | Control Schools | Total |
|---|---|---|---|
| Age, Customized 13 years | 4 Participants | 0 Participants | 4 Participants |
| Age, Customized 14 years | 4 Participants | 3 Participants | 7 Participants |
| Age, Customized 15 years | 4 Participants | 7 Participants | 11 Participants |
| Age, Customized 16 years | 7 Participants | 5 Participants | 12 Participants |
| Age, Customized 17 years | 6 Participants | 3 Participants | 9 Participants |
| Age, Customized 18 years | 1 Participants | 0 Participants | 1 Participants |
| Gender Identity Female | 19 Participants | 8 Participants | 27 Participants |
| Gender Identity Genderqueer or gender nonconforming | 0 Participants | 3 Participants | 3 Participants |
| Gender Identity Male | 5 Participants | 6 Participants | 11 Participants |
| Gender Identity Transgender Female | 1 Participants | 0 Participants | 1 Participants |
| Gender Identity Transgender Male | 1 Participants | 1 Participants | 2 Participants |
| Grade in School 10th Grade | 5 Participants | 8 Participants | 13 Participants |
| Grade in School 11th Grade | 4 Participants | 5 Participants | 9 Participants |
| Grade in School 12th Grade | 10 Participants | 4 Participants | 14 Participants |
| Grade in School 9th Grade | 7 Participants | 1 Participants | 8 Participants |
| Race/Ethnicity, Customized American Indian or Alaksa Native | 0 Participants | 1 Participants | 1 Participants |
| Race/Ethnicity, Customized Asian | 2 Participants | 7 Participants | 9 Participants |
| Race/Ethnicity, Customized Black or African American | 6 Participants | 1 Participants | 7 Participants |
| Race/Ethnicity, Customized Latino or Hispanic | 13 Participants | 10 Participants | 23 Participants |
| Race/Ethnicity, Customized Native Hawaiian or Pacific Islander | 0 Participants | 1 Participants | 1 Participants |
| Race/Ethnicity, Customized White | 9 Participants | 6 Participants | 15 Participants |
| Sex: Female, Male Female | 20 Participants | 12 Participants | 32 Participants |
| Sex: Female, Male Male | 6 Participants | 6 Participants | 12 Participants |
| Sexual Orientation Asexual | 1 Participants | 1 Participants | 2 Participants |
| Sexual Orientation Bisexual | 14 Participants | 4 Participants | 18 Participants |
| Sexual Orientation Decline to Answer | 0 Participants | 1 Participants | 1 Participants |
| Sexual Orientation Gay/Homosexual | 5 Participants | 3 Participants | 8 Participants |
| Sexual Orientation Lesbian/Homosexual | 4 Participants | 2 Participants | 6 Participants |
| Sexual Orientation Pansexual | 1 Participants | 4 Participants | 5 Participants |
| Sexual Orientation Queer | 1 Participants | 2 Participants | 3 Participants |
| Sexual Orientation Straight/Heterosexual | 0 Participants | 1 Participants | 1 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 27 | 0 / 20 |
| other Total, other adverse events | 0 / 27 | 0 / 20 |
| serious Total, serious adverse events | 0 / 27 | 0 / 20 |
Outcome results
Adapted CSSRS Suicide Questions (Columbia Suicide Severity Rating Scale)
Six items assessing current suicidality that were adapted from the longer, treatment-based Columbia Suicide Severity Rating Scale. The first two items ask about passive ideation and active ideation, and affirmative responses link to follow-up questions about methods, intent, plans, and attempts. The scale is scored as follows: 0 = no to passive ideation and no to active ideation 1. = yes to passive ideation (but no to active ideation) 2. = yes to active ideation (but no method, intent, plan) 3. = yes to method (but no intent or plan) 4. = yes to intent (but no plan) 5. = yes to plan Attempts can be scored on its own or added to the overall scale for a risk score of 6 if participant has a recent suicide attempt.
Time frame: Change between baseline and post-intervention/follow-up (12 weeks).
Population: All participants who completed the Proud \& Empowered intervention. Participants were from four high schools within Los Angeles County. Two schools were assigned to the intervention condition while the other two were assigned to the control condition. Participants were in 9th through 12th grade, and identified as sexual and/or gender minority.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intervention Schools | Adapted CSSRS Suicide Questions (Columbia Suicide Severity Rating Scale) | Time 1 (Baseline) | 0.63 score on a scale | Standard Deviation 1.31 |
| Intervention Schools | Adapted CSSRS Suicide Questions (Columbia Suicide Severity Rating Scale) | Time 2 (Post-intervention) | .71 score on a scale | Standard Deviation 1.46 |
| Control Schools | Adapted CSSRS Suicide Questions (Columbia Suicide Severity Rating Scale) | Time 1 (Baseline) | 0.5 score on a scale | Standard Deviation 1.34 |
| Control Schools | Adapted CSSRS Suicide Questions (Columbia Suicide Severity Rating Scale) | Time 2 (Post-intervention) | 0.61 score on a scale | Standard Deviation 1.24 |
Beck Anxiety Inventory (BAI)
21-item self-report assessment of anxiety symptoms. The total score is calculated by taking the sum of the 21 items. There are five responses an individual can choose from for each item, these being Not at all which is scored as a 1, Mildly, but it didn't bother me much which is scored as a 2, Moderately -- It wasn't pleasant at times which is scored as a 3, Severely -- It bothered me a lot which is scored as a 4, and Decline to answer which is scored as a 5. The total score ranges from 0-63. Higher values indicate higher self-reported anxiety: Score of 0-21 indicates low anxiety, Score of 22-35 indicates moderate anxiety, Scores of 36+ indicates potentially concerning levels of anxiety. Subscales are calculated through summation.
Time frame: Change between baseline and post-intervention/follow-up (12 weeks).
Population: All participants who completed the Proud \& Empowered intervention. Participants were from four high schools within Los Angeles County. Two schools were assigned to the intervention condition while the other two were assigned to the control condition. Participants were in 9th through 12th grade, and identified as sexual and/or gender minority.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intervention Schools | Beck Anxiety Inventory (BAI) | Time 1 (Baseline) | 22.08 score on a scale | Standard Deviation 14.44 |
| Intervention Schools | Beck Anxiety Inventory (BAI) | Time 2 (Post-intervention) | 19.56 score on a scale | Standard Deviation 16.08 |
| Control Schools | Beck Anxiety Inventory (BAI) | Time 1 (Baseline) | 26.89 score on a scale | Standard Deviation 16.75 |
| Control Schools | Beck Anxiety Inventory (BAI) | Time 2 (Post-intervention) | 27.39 score on a scale | Standard Deviation 14.14 |
Beck Depression Inventory
21-item self-report assessment of depression symptoms and severity of depression. The items are rated on a 4-point scale ranging from 0-3 based on the severity of each item (e.g., 0=I do not feel sad, 1=I feel sad much of the time, 2=I am sad all the time, and 3=I am so sad or unhappy that I can't stand it). The total range of scores is from 0-63. Higher values indicate a worse outcome and indicates a greater severity of depression. Scores of 0-13 indicates minimal depression, scores of 14-19 indicates mild depression, scores of 20-28 indicates moderate depression, scores of 29-63 indicates severe depression. Subscale values are achieved through summation.
Time frame: Change between baseline and post-intervention/follow-up (12 weeks).
Population: All participants who completed the Proud \& Empowered intervention. Participants were from four high schools within Los Angeles County. Two schools were assigned to the intervention condition while the other two were assigned to the control condition. Participants were in 9th through 12th grade, and identified as sexual and/or gender minority.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intervention Schools | Beck Depression Inventory | Time 1 (Baseline) | 15.40 score on a scale | Standard Deviation 11.54 |
| Intervention Schools | Beck Depression Inventory | Time 2 (Post-intervention) | 15.68 score on a scale | Standard Deviation 11.96 |
| Control Schools | Beck Depression Inventory | Time 1 (Baseline) | 17.81 score on a scale | Standard Deviation 9.56 |
| Control Schools | Beck Depression Inventory | Time 2 (Post-intervention) | 18.65 score on a scale | Standard Deviation 12.77 |
Coping Strategies Inventory
16-item assessment measuring specific coping strategies people use in response to stressful events. Individuals respond to 16 items, with each item assessing components of Problem Solving, Cognitive Restructuring, Social Support, Express Emotions, Problem Avoidance, Wishful Thinking, and Social Withdrawal. Individuals can respond in 5 different ways, these being Never, Seldom, Sometimes, Often, or Almost Always. These responses are scored from 1-5 with Never being a 1 and Almost Always being a 5. The total score is a summation of item scores with a range from 16-80. Higher scores in a particular primary scale indicates that the individual implements that form of coping strategy more often.
Time frame: Change between baseline and post-intervention/follow-up (12 weeks).
Population: All participants who completed the Proud \& Empowered intervention. Participants were from four high schools within Los Angeles County. Two schools were assigned to the intervention condition while the other two were assigned to the control condition. Participants were in 9th through 12th grade, and identified as sexual and/or gender minority.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intervention Schools | Coping Strategies Inventory | Time 1 (Baseline) | 49.96 score on a scale | Standard Deviation 15.23 |
| Intervention Schools | Coping Strategies Inventory | Time 2 (Post-intervention) | 47.64 score on a scale | Standard Deviation 16.25 |
| Control Schools | Coping Strategies Inventory | Time 1 (Baseline) | 47.85 score on a scale | Standard Deviation 12.48 |
| Control Schools | Coping Strategies Inventory | Time 2 (Post-intervention) | 49.26 score on a scale | Standard Deviation 14.22 |
PTSD Checklist for DSM-5 (PCL-5)
20-item self-report assessment of post-traumatic stress disorder (PTSD) symptoms which addresses all 20 DSM-5 symptoms of PTSD. A total symptom severity score can be calculated by summing the scores for each of the 20 items. Each item has five possible responses including Not at all which is scored as a 0, A little bit which is scored as a 1, Moderately which is scored as 2, Quite a bit which is scored as a 3, and Extremely which is scored as a 4. The potential range of scores is 0-80. Higher scores indicate a worse outcome where the individual has higher severity of PTSD symptoms.
Time frame: Change between baseline and post-intervention/follow-up (12 weeks).
Population: All participants who completed the Proud \& Empowered intervention. Participants were from four high schools within Los Angeles County. Two schools were assigned to the intervention condition while the other two were assigned to the control condition. Participants were in 9th through 12th grade, and identified as sexual and/or gender minority.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intervention Schools | PTSD Checklist for DSM-5 (PCL-5) | Time 1 (Baseline) | 21.81 score on a scale | Standard Deviation 18.3 |
| Intervention Schools | PTSD Checklist for DSM-5 (PCL-5) | Time 2 (Post-intervention) | 24.40 score on a scale | Standard Deviation 19.08 |
| Control Schools | PTSD Checklist for DSM-5 (PCL-5) | Time 1 (Baseline) | 26.78 score on a scale | Standard Deviation 20.34 |
| Control Schools | PTSD Checklist for DSM-5 (PCL-5) | Time 2 (Post-intervention) | 29.28 score on a scale | Standard Deviation 17.32 |
Sexual Minority Adolescent Stress Inventory (SMASI)
54-item survey across 10 domains of minority stress. Assesses experiences of minority stress among adolescents. Each statement reflects past-30-day thoughts, feelings, and situations a person may have experienced, with response options of 1 = yes and 0 = no. A total score was calculated by summing the 54 items. The total score ranged from 0-54. Higher values correspond to a worse outcome, meaning the individual in question has had more stressful experiences.
Time frame: Change between baseline and post-intervention/follow-up (12 weeks).
Population: All participants who completed the Proud \& Empowered intervention. Participants were from four high schools within Los Angeles County. Two schools were assigned to the intervention condition while the other two were assigned to the control condition. Participants were in 9th through 12th grade, and identified as sexual and/or gender minority.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Intervention Schools | Sexual Minority Adolescent Stress Inventory (SMASI) | Time 1 (Baseline) | 8.44 score on a scale | Standard Deviation 6.65 |
| Intervention Schools | Sexual Minority Adolescent Stress Inventory (SMASI) | Time 2 (Post-intervention) | 7.59 score on a scale | Standard Deviation 7.13 |
| Control Schools | Sexual Minority Adolescent Stress Inventory (SMASI) | Time 1 (Baseline) | 7.22 score on a scale | Standard Deviation 7.12 |
| Control Schools | Sexual Minority Adolescent Stress Inventory (SMASI) | Time 2 (Post-intervention) | 8.29 score on a scale | Standard Deviation 7.68 |
Youth Risk Behavior Survey Substance Use Questions
Measures individual's usage of various substances in their lifetime and within the past 30 days as well as the ways in which individuals have used marijuana, tobacco, or nicotine in the past 30 days. Each substance is individually analyzed for both lifetime usage and past 30 day usage. Individuals can answer Yes or No for both lifetime usage and past 30 day usage. Each substance can range from 0 to the maximum number of survey responses. In addition, for marijuana, students can specify the way in which they used it with response options of smoking, vaping, edible or beverage form, or other. For nicotine and tobacco, students can specify the way in which they used it with the response options of smoking, vaping, or other. Yes responses indicate a worse outcome indicating that individuals have used or are currently using the substance in question.
Time frame: Change between baseline and post-intervention/follow-up (12 weeks).
Population: All participants who completed the Proud \& Empowered intervention. Participants were from four high schools within Los Angeles County. Two schools were assigned to the intervention condition while the other two were assigned to the control condition. Participants were in 9th through 12th grade, and identified as sexual and/or gender minority.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Alcohol Use : Time 1 (Baseline) | 11 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Tranquilizers Use : Time 1 (Baseline) | 0 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Marijuana Use : Time 1 (Baseline) | 9 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Tranquilizers Use : Time 2 (Post-intervention) | 0 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Tobacco Use : Time 1 (Baseline) | 6 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Stimulants Use : Time 1 (Baseline) | 0 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Alcohol Use : Time 2 (Post-intervention) | 12 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Stimulants Use : Time 2 (Post-intervention) | 1 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Tobacco Use : Time 2 (Post-intervention) | 5 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Marijuana Use : Time 2 (Post-intervention) | 10 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Pain Relievers Use : Time 2 (Post-intervention) | 1 participants |
| Intervention Schools | Youth Risk Behavior Survey Substance Use Questions | Pain Relievers Use : Time 1 (Baseline) | 3 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Pain Relievers Use : Time 2 (Post-intervention) | 1 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Alcohol Use : Time 2 (Post-intervention) | 7 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Tobacco Use : Time 1 (Baseline) | 2 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Tobacco Use : Time 2 (Post-intervention) | 4 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Pain Relievers Use : Time 1 (Baseline) | 1 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Stimulants Use : Time 2 (Post-intervention) | 0 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Alcohol Use : Time 1 (Baseline) | 5 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Tranquilizers Use : Time 1 (Baseline) | 0 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Tranquilizers Use : Time 2 (Post-intervention) | 0 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Stimulants Use : Time 1 (Baseline) | 0 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Marijuana Use : Time 1 (Baseline) | 0 participants |
| Control Schools | Youth Risk Behavior Survey Substance Use Questions | Marijuana Use : Time 2 (Post-intervention) | 1 participants |