Chronic Stable Angina Pectoris
Conditions
Keywords
meridians, acupuncture, chronic stable angina pectoris, meridian phenomenon, near infrared spectroscopy
Brief summary
Although some important progresses were made in the field of the meridian research, no breakthroughs have been achieved. Besides,there are some problems in meridian researches. Particularly, previous research of meridian phenomenon involved lots of subjective elements and outcomes.Researches that use modern scientific techniques to investigate the biological characteristics of meridian phenomenon are urgently needed. Therefore, this study is designed to assess the metabolic characteristics of meridian phenomenon for the Heart and Lung meridians by using near infrared spectroscopy. Thus, the biological characteristics of meridian phenomenon could be presented objectively in a scientific methodology.
Detailed description
This study will include 40 patients diagnosed with chronic stable angina pectoris (CSAP) and 40 healthy volunteers. Near infrared spectroscopy will be adopted to assess the metabolic characteristics of meridian phenomenon for Heart and Lung meridians in the physiology/pathological state. In addition, by comparing the metabolic characteristics in the acupoints along the Heart and Lung meridians, the relative specificity of the two meridians will also be investigated. Primary outcomes will be regional oxygen saturation (rSO2). Furthermore, this study will build standardized techniques and schemes for detecting the metabolic characteristics of meridian phenomenon for Heart and Lung. The results of this study could also provide scientific foundation for traditional meridian theories.
Interventions
DEVICENear infrared spectroscopy
Near infrared spectroscopy will be adopted to assess the microcirculatory characteristics of meridian phenomenon for participants in the two groups. 1. Experimental device: a four-channel INVOS 5100C Oximeter (Somanetics Corp., Troy, USA) 2. Experimental process: The participants will be allowed to stabilize for 15 minutes in a supine position in the experimental room before formal examination. They are asked to keep silent, breathe normally and avoid movement of limbs during the whole measuring period. After ripping the transparent adhesive tape on the probe, the probes will be left at 4 measuring sites. Regional oxygen saturation (rSO2) will be recorded for 5 minutes. 3. Measurement sites: Shenmen (HT7) and Shaohai (HT3) of the Heart meridian, Taiyuan(LU9) and Chize (LU5) of the Lung meridian.
Sponsors
The Third Affiliated hospital of Zhejiang Chinese Medical University
The First Affiliated Hospital of Zhejiang Chinese Medical University
Zhejiang Chinese Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria for CSAP 1. Patients should meet the diagnostic criteria of coronary heart disease, which includes the following items: 1)confirmed old myocardial infarction (MI), or a history of percutaneous coronary intervention(PCI), or coronary artery bypass grafting; 2)50% or more luminal stenosis in at least one coronary artery or major branch segment confirmed by coronary angiogram or CT angiography; 3) myocardial ischemia indicted by exercise stress radionuclide myocardial imaging; 4) treadmill exercise testing is positive (for male patients); 2. Patients should meet the diagnostic criteria of CSAP and the Canadian Cardiovascular Society(CCS) classification for CSAP is level II or III; 3. The medical history of angina pectoris ≥3 months, with at least 2 episodes per week in the last month; 4. 35 ≤ age ≤65 years, male or female; 5. Patients have clear consciousness and could communicate with others normally; 6. Patients could understand the full study protocol and have high adherence. Written informed consent is signed by themselves or their lineal kin. Inclusion criteria for health volunteers 1. Healthy volunteers who could provide a recent (in the past 3 month) medical examination report to confirm they have not any cardiovascular, respiratory, digestive, urinary, hematological, endocrine and neurological disease; 2. 35 ≤ age ≤65 years, male or female; 3. Participants have clear consciousness and could communicate with others normally; 4. Participants could understand the full study protocol and have high adherence .Written informed consent is signed by themselves or their lineal kin.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regional oxygen saturation (rSO2) | 5 minutes | Regional oxygen saturation could reflect the metabolic characteristics of meridians phenomenon. |
Countries
China
Contacts
Primary ContactYongliang Jiang, Ph.D
Backup ContactHantong Hu
Outcome results
None listed