Low Anterior Resection Syndrome
Conditions
Keywords
Rectal cancer, low anterior resection, low anterior resection syndrome
Brief summary
* Aim: The aim of this study is to perform a prospective, international 4 months cohort study evaluating bowel function before curative rectal cancer surgery and one year after the surgery using the LARS score. * Primary outcome measure: LARS score before surgery and 1 year after the surgery. * Primary comparison: Between average LARS score before and after curative surgery and also comparing these with publish LARS score on normal population.
Detailed description
All patients undergoing treatment for rectal rectal will be included in the study. Before any treatment all the included patients will be asked to fill the LARS score (5 question questionnaire with differently weighted answers for assessing the low anterior resection score). One year after the low anterior resection (without the stoma) or following the stoma take down patients will be reassessed. The LARS score will be filled one again. Patient characteristics, age, cancer stage, level of anastomosis will be assessed aswel.
Interventions
DIAGNOSTIC_TESTPatients undergoing low anterior resection
Patients before the surgery and one year after the surgery will be assessed with questionnaire.
Sponsors
King's College London
National Cancer Institute (NCI)
National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing rectal cancer surgery on curative intent. * Elective surgery patients. * Laparoscopic, laparoscopic-converted, robotic, TaTME (transanal total mesorectal excision) and open cases will be included. * Patients aged 18 years and over should be included.
Exclusion criteria
* Patients undergoing a procedure purely for diagnosis or staging should be excluded. * Patients with palliative treatment. * Patients with recurrence should be excluded. * Patients with dementia * Patients who do not complete their treatment within 12 months of primary surgery e.g. including reversal of stoma, chemotherapy etc
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| LARS score change comparing before surgery and 1 year after the surgery. | 12 months | Low anterior resection score is a simple questionnaire consisting of five simple questions for bowel function assessment after anterior resection. The maximum number is between 0 and 42. No LARS (good bowel function) is from 0 to 20; minor LARS - 21-29 and major LARS (poor bowel function) more than 29. Between average LARS score before and after curative surgery and also comparing these with published LARS score on normal population. |
Countries
Lithuania
Contacts
Primary ContactAudrius Dulskas, MD, PhD
Backup ContactPovilas Kavaliauskas, MD
Outcome results
None listed