Aortic Regurgitation, Mitral Regurgitation
Conditions
Brief summary
The primary treatment for patients determined to have severe aortic or mitral regurgitation is surgical repair or replacement their valves. The most commonly used tool to quantify the severity mitral and aortic regurgitation is echocardiography. Studies have shown that echocardiography may have significant limitations in quantifying regurgitant volume. MRI has recently been shown to easily and reproducibly quantify regurgitation. To better understand how to accurately quantify severity of regurgitation the investigators propose this study with the following aims: 1) compare MRI to echocardiography in the evaluation of regurgitant volume in patients with aortic or mitral regurgitation and 2) to assess which technique is better at predicting the response of the left ventricle to valve surgery.
Detailed description
The primary treatment for patients determined to have severe aortic or mitral regurgitation is surgical repair or replacement their valves. The most commonly used tool to quantify the severity mitral and aortic regurgitation is echocardiography. Studies have shown that echocardiography may have significant limitations in quantifying regurgitant volume. MRI has recently been shown to easily and reproducibly quantify regurgitation. To better understand how to accurately quantify severity of regurgitation the investigators propose this study with the following aims: 1) compare MRI to echocardiography in the evaluation of regurgitant volume in patients with aortic or mitral regurgitation and 2) to assess which technique is better at predicting the response of the left ventricle to valve surgery.
Interventions
DIAGNOSTIC_TESTMRI
MRI of the heart
Sponsors
Atlantic Health System
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age ≥18 years of age * Able to give informed consent * Referred for isolated aortic or mitral valve repair or replacement due to valve regurgitation
Exclusion criteria
* Inability to provide consent. * Pregnancy * Claustrophobia * Metallic contraindications to MRI (e.g. noncompatible aneurysm clip etc) * Known intracardiac shunt * Planned concomitant cardiac surgical procedure such as coronary artery bypass, septal myomectomy, or other valve procedure. * More than mild mitral or aortic stenosis. * For patients enrolled with mitral regurgitation: greater than mild aortic regurgitation. * For patients enrolled with aortic regurgitation: greater than mild mitral regurgitation. * Hypertrophic cardiomyopathy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of echocardiography and MRI | 6 month | Correlation of echocardiography and MRI |
| Change in LV EDV post surgery | 6 month | Change in LV EDV post surgery |
Countries
United States
Outcome results
None listed