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Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure

Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04035915
Enrollment
126
Registered
2019-07-29
Start date
2019-07-25
Completion date
2021-03-31
Last updated
2021-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS, on Invasive Mechanical Ventilation, Respiratory Failure

Keywords

Limited driving pressure, Low tidal volume, Lung injury score

Brief summary

Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure.

Detailed description

Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure. To compare lung injury score (LIS, Murray score) after invasive mechanical ventilation 7 days between groups of limited driving pressure ventilation versus low tidal volume ventilation strategies.

Interventions

PROCEDURELimited driving pressure

Keep driving pressure \<15 cmH2O

PROCEDUREConventional mechanical ventilation strategies

Keep tidalvolume \</= 8

Sponsors

Mahidol University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age ≥ 18 year old MICU patient * On Invasive mechanical ventilator less than 24 hr. before randomization

Exclusion criteria

* Suspected death within 48 hr. after randomization * patients with tracheostomy tube * Pregnancy * Do not attempt resuscitation order * Patient with ECMO before randomization

Design outcomes

Primary

MeasureTime frameDescription
Lung injury scoreDay 7 after invasive mechanical ventilationLung injury score (LIS, Murray score)

Secondary

MeasureTime frameDescription
28 days MortalityUpto 28 days28 days Mortality
New onset of ARDSUpto 28 daysNew onset of ARDS

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026