Inpatient Package to Reduce HIV and AIDS-related Death in Zambia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04033718

Acronym

IPADZ

Enrollment

Registered

2019-07-26

Start date

2021-10-01

Completion date

2024-06-30

Last updated

2024-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cryptococcosis, HIV/AIDS, HIV Testing, Hospitalization, Transitions of Care, Tuberculosis

Brief summary

Early post-discharge mortality is high among HIV-infected Zambians admitted to the hospital. Likely this is in part due to missed opportunities to identify lethal coinfections and optimize HIV care during admission (and before discharge). In this study the investigators will develop and pilot a new approach to inpatient HIV care that follows international guidelines for management of advanced HIV disease.

Interventions

DIAGNOSTIC_TESTInpatient lab bundling

The investigators will provide patients a package of diagnostic tests at the time of admission to comprehensively assess for HIV coinfections and treatment failure. These labs are all recommended in advanced HIV guidelines but in this study we will provide all tests as a bundle rather than step-by-step as suggested in guidelines.

BEHAVIORALInpatient navigation

Participants will be assigned a patient navigator who will support the patient and bedsider (treatment supporter/guardian) during the hospitalization. The navigator will be an HIV counselor who can provide counseling and health education, as well as support specimen transport, obtaining results, booking tests in other departments, linkages to ART clinic, and discharge planning

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18+ years old * HIV-positive (by self-report or DCT result in UTH file) * Resident of Lusaka * Admitted to the hospital

Exclusion criteria

* Too sick to provide informed consent (based on clinician opinion) * Likely to be discharged in the next 48 hours (based on clinician opinion)

Design outcomes

Primary

Measure	Time frame	Description
Coinfection diagnosis	Through hospital discharge, an average of 2 weeks	Positive test for tuberculosis or cryptococcus on admission

Countries

Zambia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026