Combined Epidural Morphine and Midazolam on Postoperative Pain

Effect of Epidural Morphine and Midazolam on Postoperative Painin Patients Undergoing Major Abdominal Cancer Surgery

Status

UNKNOWN

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04033471

Enrollment

Registered

2019-07-26

Start date

2019-07-01

Completion date

2021-04-30

Last updated

2021-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Postoperative Pain

Keywords

epidural, morphine, midazolam, acute postoperative pain

Brief summary

this study aim to Compare the effect of preoperative Epidural Midazolam, Morphine and their combination in postoperative pain relief and total morphine consumption.

Detailed description

Major abdominal surgeries with abdominal incisions lead to severe abdominal pain, which if treated inadequately, can cause shallow breathing, atelectasis, retention of secretions and lack of cooperation in physiotherapy. This increases the incidence of post-operative morbidity and leads to delayed recovery.Epidural anesthesia is safe and inexpensive technique with the advantage of providing surgical anesthesia and prolonged postoperative pain relief. It also an effective treatment of operative pain blunts autonomic, somatic and endocrine responses. Morphine and midazolam can be used as adjuvant to bupivicain to reduced the postoperative pain

Interventions

DRUGmidazolam

epidural needle in the L1-2 or L2-3 space , and using loss of resistance technique udder strict aseptic condition 10 ml of the prepared drug will be given

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Intervention model description

epidural bupiviacain

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

* ASA I-II patients scheduled for major abdominal cancer surgeries

Exclusion criteria

* patients with known allergy to the study drugs, * significant cardiac, respiratory, renal or hepatic disease, * drug or alcohol abuse, * psychiatric illness that would interfere with perception and assessment of pain.

Design outcomes

Primary

Measure	Time frame	Description
time to first request of analgesia	1st 48 hours postoperative	the time between the end of operation and tracheal extubation to the first request for supplemental analgesics and its administration to the patient

Secondary

Measure	Time frame	Description
the cumulative consumption of morphine in the 1st 48h postoperatively	1st 48 hours postoperative	total amount of morphine used for analgesia

Countries

Egypt

Contacts

Primary ContactShereen M Kamal, Associate proferssor

sheridouh79@yahoo.com01006279209

Backup ContactKhaled M Fares, proferssor

faressali@yahoo.com01289757288

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026