Early Onset Parkinson Disease, Early Stage Parkinson Disease
Conditions
Keywords
Executive function, Dual-task performance, Dual-task training
Brief summary
This study aimed to investigate the effects of Game based dual-task training with treadmill on executive function and dual-task performance in individuals with early-onset PD and discuss the correlation between the change values of executive function and dual-task performance after training. Besides, investigate cortical activation after training.
Interventions
OTHERGame based dual-task training
Participants in the experimental group will receive game based dual-task training with a treadmill
OTHERTreadmill training
Participants in the control group will receive treadmill training
Sponsors
National Yang Ming Chiao Tung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed as PD and Hoehn and Yahr stage between 1\ 3 * Age between 20 to 80 * Able to walk 10 m independently without an assistive device * A score of greater than or equal to 24 on the mini-mental state examination (MMSE) * In stable medical condition allowing participation in the testing protocol and intervention
Exclusion criteria
* Any comorbidity or disability other than PD that would preclude gait training * Any uncontrolled health condition for which exercise was contraindicated * Any neurological or orthopedic disease that might interfere with the study * Server freezing of gait, FOG questionnaire \> 15
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dual-task walking performance | Change from baseline at 8 weeks | To evaluate gait parameters while doing dual-task walking |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Single walking performance | Change from baseline at 8 weeks | To evaluate gait parameters while doing single walking |
| Timed up and go test | Change from baseline at 8 weeks | To evaluate functional walking ability |
| Parkinson's Disease Questionnaire 39 | Change from baseline at 8 weeks | To evaluate the quality of life |
| Frontal lobe battery test-Chinese version | Change from baseline at 8 weeks | To evaluate executive function |
| Trail-making test | Change from baseline at 8 weeks | To evaluate executive function |
| Stroop color and word test-Chinese version | Change from baseline at 8 weeks | To evaluate executive function |
| Verbal fluency test-Chinese version | Change from baseline at 8 weeks | To evaluate executive function |
| Digit span test | Change from baseline at 8 weeks | To evaluate executive function |
| Dual-task costs | Change from baseline at 8 weeks | To compare the cost between doing dual task and single task |
| Functional near-infrared spectroscopy | Change from baseline at 8 weeks | To evaluate the changes of blood perfusion in frontal lobe |
Contacts
Primary ContactYang Yearu, Ph.D.
Outcome results
None listed