Squamous Cell Carcinoma of the Oropharynx
Conditions
Keywords
F-Miso PET scan, Magnetic resonance imaging, immunohistochemistry, Head and neck cancer
Brief summary
Hypoxia imaging has not been studied extensively by combining PET and MRI data. Few studies performed the double imaging and none associated anatomopathology with it . This study will use a rigorous methodology through the production of PET/MRI images at the same time by transferring the patient directly from PET to MRI. In addition, the population, unlike other studies, will include preoperative patients with 24-hour surgery for hypoxia imaging by obtaining additional data through specific immunohistochemical analysis of hypoxia.
Interventions
DRUGF-Miso PET scan coupled with MRI
Patient will undergo F-Miso PET and MRI before surgery for their head and neck cancer. Hypoxia detect with imaging will be correlated with hypoxia detected by immunohistochemistry on tumour biopsy
Sponsors
Centre Henri Becquerel
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with squamous cells carcinoma of oropharynx * Age Superior to 10 years old * Male or Female * measurable target according RECIST criteria
Exclusion criteria
* -Other histologic cancer than squamous cells carcinoma of oropharynx * No measurable target * Presence of metastasis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of biodistribution of F-Miso PET scan in pre-therapeutic and sequences of MRI in patient with squamous cells carcinoma of oropharynx | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of F-Miso PET scan and Magnetic resonance imaging to measure hypoxia | 1 year |
| Correlation between recurrence free survival at one year and rate of hypoxia determined by the 3 techniques (PET scan, MRI and IHC) | 1 year |
Countries
France
Outcome results
None listed