Effects of Anesthetic Techniques on Renal Function

Different Effects of Two Anesthetic Techniques on Renal Function During the Perioperative Period of Cardiac Surgery in Children

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04030481

Enrollment

Registered

2019-07-24

Start date

2019-01-01

Completion date

2019-09-30

Last updated

2019-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Congenital Heart Disease

Keywords

propofol,sevoflurane

Brief summary

This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.

Detailed description

Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.

Interventions

OTHERinhalation anesthesia

sevoflurane was used to maintain anesthesia

OTHERTotal intravenous anesthesia

propofol was used to maintain anesthesia

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Minutes to 3 Years

Healthy volunteers

Inclusion criteria

* children with congenital heart disease * \<3 years of age

Exclusion criteria

* preoperative renal insufficiency; * renal malformation, kidney absence

Design outcomes

Primary

Measure	Time frame	Description
renal blood flow	2 days	Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s)

Secondary

Measure	Time frame	Description
neutrophil gelatinase-associated lipocalin , NGAL	2 days	Changes of blood NGAL were obtained before and 2 hours after surgery, unit(ng/ml)
creatinine	3 and 4 days	Changes of creatinine before and 3 days after acquisition, unit (mmol/L)
Mean arterial pressure	2 days	Mean arterial pressure synchronized with renal blood flow was recorded, unit (mmHg)
cardiopulmonary bypass (CPB) time	24 hours	Cardiopulmonary bypass time was recorded, unit(minutes)

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026