Cardiac Surgery
Conditions
Brief summary
The purpose of the study was to verify the protective effect of inhibiting systemic inflammatory response in patients undergoing cardiac surgery.
Interventions
DRUGUlinastatin
Ulinastatin 5000U/Kg in 20 ml NS i.v. before occlusion of aorta
Sponsors
Shanghai Zhongshan Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* subject needs to have valve surgery * subject needs to have coronary artery bypass grafting surgery * subject needs to have artificial blood vessel replacement surgery * ASA(American Society of Anesthesiologists) score II\ III * NYHA(New York Heart Association) II\ III
Exclusion criteria
* LVEF(left ventricular ejection fraction) \<40% measured by echocardiogram * history of myocardial infarction within 1 month * history of serious pulmonary infection or endocarditis within 3 months * history of important surgery within 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative delirium | 7 days postoperatively or discharge, whichever came first | the incidence of postoperative delirium |
| postoperative renal insufficiency | 7 days postoperatively or discharge, whichever came first | the incidence of renal insufficiency |
Contacts
Primary ContactKe-fang Guo, PhD
Outcome results
None listed