VKH Syndrome
Conditions
Keywords
VKH; immune profile;
Brief summary
The investigators will collect blood samples of different courses of VKH patients for investigating immune profile, observe major immune cells number ,functional and membrane molecular changes in the course of treatment, to investigate pathogenesis of VKH. Meanwhile, the investigators will collect clinical data of VKH patients to observe choroid and retina change in different courses.
Interventions
DRUGSteroids
IV and oral steroids
Sponsors
Aier School of Ophthalmology, Central South University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. Acute VKH patients, meet a criterion of VKH, no recurrence. 2. Age range from 18 to 50 years old.
Exclusion criteria
1. Patients with Severe Cardiovascular and Cerebrovascular Diseases 2. Patients allergic to steroid or contrast agents; 3. A history of ocular trauma or intraocular surgery within 3 months; Vaccinated; History of infectious diseases 4. having a history of heredity, immune system correlation, neuroendocrine and digestive system diseases 5. Patients who take health care products for a long time and have heavy alcohol and tobacco addiction.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| T/B /NK(natural killer )/monocyte...etc, cell numbers of blood samples in VKH patients | one year | use flow cytometry to count T/B /NK/monocyte...etc, cell numbers |
| T/B /NK/monocyte...etc cell subtype proportion in blood samples in VKH patients | one year | use flow cytometry to measure T/B /NK/monocyte...etc cell subtype proportion |
| T/B /NK/monocyte...etc cell functional change in VKH patients | one year | use ELISA(enzyme linked immunosorbent assay) to measure inflammatory cytokines level in peripheral blood |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| choroid and retinal thickness change in different course of VKH patients | one year | Use OCT（optical coherence tomography） to measure choroid and retina thickness changes in macular zone of different course VKH patients |
| measure the Injury degree of choroid and retinal vessels | one year | Use FFA(fluorescein fundus angiography)/ICG(Indocyanine Green Angiography) to measure the Injury degree of choroid and retinal vessels |
| Use OCTA(optical coherence tomography angiography) to measure macular and optic disc vascular index | one year | Use OCTA to measure macular and optic disc vascular index in different course VKH patients |
| Use Maia perimeter to measure macular integrality | one year | Use Maia perimeter to measure macular integrality including light threshold and central fixation. |
Countries
China
Contacts
Primary ContactZhaohui Li, Ph.D/MD
Backup ContactYafei Huang, Ph.d
Outcome results
None listed