Ovarian Insufficiency, Poor Ovarian Response
Conditions
Brief summary
Improving the results of in vitro fertilization in women with poor ovarian response and early ovarian insufficiency
Detailed description
BACKGROUND: Mechanical disruption of the Hippo signaling pathway in the ovaries can increase the likelihood of pregnancy and childbirth in women with early ovarian insufficiency. The method may also work in women with poor ovarian reserve and poor response to routine fertility treatments. OBJECTIVE: To examine whether mechanical stimulation of ovaries by cutting the ovarian cortex treatment can increase eggs number aspirated during In Vitro Fertilization (IVF). METHODS: Patients eligible for the study with poor ovarian response will receive treatment including laparoscopic surgery, resection, and transplantation of ovarian tissue in the same operation to improve the chances of IVF success and pregnancy. Participants will be assessed for surgical incisions and fertility assessment up to two weeks after treatment, including general physical examination, US pelvic examination, and blood tests for a hormonal profile to determine the initiation of ovarian stimulation and IVF. Patients will be monitored from 2 weeks to 1 year after treatment (once a week in the first two months and one month for one year after surgery), which will include a general physical examination, a pelvic ultrasound (US) and blood tests for the hormonal profile at the IVF clinic.
Interventions
PROCEDUREIn Vitro Fertilization
Patients suitable for research with poor ovarian response will receive treatment including laparoscopic surgery, resection, and transplantation of ovarian tissue in the same operation to improve the chances of success of in vitro fertilization and pregnancy. Participants will be assessed for surgical incisions and fertility assessment up to two weeks after treatment, including general physical examination, US pelvic examination, and blood tests for a hormonal profile to determine the initiation of ovarian stimulation and IVF. Patients will be monitored from 2 weeks to 1 year after treatment (once a week in the first two months and one month for one year after surgery), which will include a general physical examination, a US test, and blood tests for the hormonal profile at the IVF clinic.
Sponsors
Barzilai Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Volunteers with poor ovarian response to standard fertility treatments according to the criteria of the European Fertility Association (ESHRE). * Diagnosis of early ovarian insufficiency or symptoms that predict early ovarian insufficiency (imminent) seeking to become pregnant.
Exclusion criteria
Volunteers with * Severe endometriosis diagnosed with laparoscopy. * Previous major surgery involving ovaries. * Ovarian cancer. * Female reproductive malformations. * Contraindications for laparoscopic surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of oocytes | up to 1 year | Number of oocytes |
| Fertilization rate | up to 1 year | Fertilization rate |
| Embryos number | up to 1 year | Embryos number |
| Pregnancies rate | up to 1 year | Pregnancies rate |
Countries
Israel
Outcome results
None listed