Arthropathy, Moderate Hemophilia
Conditions
Brief summary
The management of moderate hemophilia is less codified than those of severe patients; because these patients are theoretically less likely to bleed and therefore less likely to develop arthropathies. Nowaways, the question arises as to the appropriateness of this "symptomatic" management for the prevention of the occurrence of hemophilic arthropathies. Indeed, a significant number of moderate hemophiliacs seems to develop severe arthropathies that cause significant disability. However, because of the very small proportion of these patients in the total number of hemophiliacs, data are lacking on the impact of arthropathies on this population. The investigators therefore propose to include moderate hemophiliac patients in the study to carry out an evaluation of gait, using a gait analysis to determine the consequences of arthropathies, even sub-clinical ones, according to the duration of the disease's progression. In an associated way, the analysis of different clinical (joint assessment; quality of life score;...), radiological (radiographic; ultrasound (synovial thickness)), biological (level of associated factors ; other associated marker), in order to provide a complete picture of the articular situation in these patients with moderate haemophilia.
Interventions
OTHERGait analysis
The duration of participation of each subject is equal to the duration of the examination, i.e. approximately 30 minutes for the gait analysis and 30 minutes for the clinical examination (including 10 minutes for completing the questionnaire). The experiments will be carried out in a single measurement session, including several steps.
Sponsors
Nantes University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Each participant will perform the quantified gait analysis examination and a clinical examination. The experiments will be carried out in a single measurement session, including several steps.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Have moderate Hemophilia A or B. * Have understood the protocol and signed its consent to participate. * Patient able to perform a walking test. * Patient affiliated to a social security system
Exclusion criteria
* Pregnant women * Minor * Majors under guardianship or curatorship * Refusal to participate; * Amputee of a lower limb * Need for technical walking assistance (walking sticks, walker,...). * Extensive dermatitis of the lower limbs (need for sensor installation for gait analysis); * Known NYHA (New York Heart Association) grade III or IV heart failure (resting dyspnea); * Unstable angina or myocardial infarction within three months of inclusion * Known severe respiratory disease; * Parkinson's disease, hemiplegia or paraplegia * Patient unable to understand the objectives or instructions of the study * Intercurrent pathology likely to modify walking abilities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of spatio-temporal parameters of the gait in moderate hemophiliac patients according to the duration of disease : | during gait analysis and clinical examination (1 hour) | Analysis of gait parameters |
| Analysis of kinematic datas of the gait in moderate hemophiliac patients according to the duration of disease : | during gait analysis and clinical examination (1 hour) | motion capture by optoelectronic system: articular amplitudes at different walking times |
| Analysis of dynamic datas of the gait in moderate hemophiliac patients according to the duration of disease : | during gait analysis and clinical examination (1 hour) | accelerations measured by the force platforms during the passage of the subject: moments of force at the different joints during the different walking times |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Calculation of the Gait profile Score (GPS) | during gait analysis and clinical examination (1 hour) | As the Gait Profile Score represents the difference between the patient's data and the average from the reference dataset, the higher the Gait Profile Score value is, the less physiological gait pattern is. |
| Assessment of joint pain | during gait analysis and clinical examination (1 hour) | pain (anlog visual scale from 0 (no pain) to 10 (maximal pain)) |
| Assessment of joint health | during gait analysis and clinical examination (1 hour) | Hemophilia Joint Health score (from 0 (best score) to 25 (worse score)) |
| X-rays of target joints | during gait analysis and clinical examination (1 hour) | Evaluated by Pettersson's score for hips, knees and ankles (score from 0 (normal score) to 10 (worse score)) |
| Look for synovial hypertrophy by measuring the variation in synovial thickness of the ankles and knees | during gait analysis and clinical examination (1 hour) | Ultrasound of knees and ankles |
| evaluation of bleeding and possible increase in synovial angiogenesis | during gait analysis and clinical examination (1 hour) | Measure of doppler activity |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORAlban Fouasson Chailloux, Dr
Nantes University Hospital
Outcome results
None listed