Cornea Folds and Rupture of Bowman's Membrane Both Eyes, Hypotony Ocular, Maculopathy
Conditions
Brief summary
The goal of this is to evaluate the biomechanical properties of hypotonous eyes with vertical anterior corneal striae and/or hypotony maculopathy compared to hypotonous eyes without striae.
Interventions
OTHEROphthalmic imaging
Optical coherence tomography Topography Ocular Response Analyzer Optical Biometry Slit lamp photos
Sponsors
Duke University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Subjects \>= 18 years of age * History of glaucoma * History of glaucoma surgery * Intraocular pressure of equal to or less than 10 mm Hg by goldmann applanation
Exclusion criteria
* Coexisting ocular disease that may affect ocular biomechanics, including macular disease, corneal transplant, and uveitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of anterior corneal striae | Baseline | Frequency of occurrence among all enrolled hypotonous eyes |
| Incidence of hypotony maculopathy | Baseline | Frequency of occurrence among all enrolled hypotonous eyes |
| Corneal hysteresis | Baseline | Difference in postoperative corneal hysteresis (measured in mm Hg) by Ocular Response Analyzer, between study arms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Axial length | Baseline | Difference in postoperative axial length between study arms |
| Corneal resistance factor | Baseline | Difference in postoperative corneal resistance factor between study arms |
| Corneal thickness | Baseline | Difference in postoperative corneal thickness between study arms |
| Corneal curvature | Baseline | Difference in postoperative diopters of steepest cornea axis, flattest cornea axis and astigmatism between study arms |
Countries
United States
Outcome results
None listed