Mucosal Ulceration
Conditions
Keywords
platelet rich fibrin (PRF)
Brief summary
Determine if the use of platelet rich fibrin (PRF) improves the rate and quality of healing for intraoral mucosal and epithelial soft tissue defects.
Interventions
PROCEDUREPlatelet Rich Fibrin Application
Platelet Rich Fibrin application at first post-op visit.
Sponsors
University of Florida
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Three categories of patients will be included in this study: 1. Osteoradionecrosis (ORN) or medication related osteonecrosis of the jaw (MRONJ) patients who present to clinic with exposed bone and no clinical sign of infection. 2. Patients having an excisional biopsy in clinic performed under local anesthesia resulting in a defect that cannot be easily repaired without compromising normal anatomy or function. These situations include excisions which would result in primary closure under tension or with distorted anatomy, require a local flap, or require healing by secondary intention. 3. Patients presenting to the post-operative clinic with intraoral surgical wound dehiscence or an intraoral surgical wound healing by secondary intention.
Exclusion criteria
* Patients under 18 years of age. * Patient's unable to participate in blood draw either due to medical compromise, inability to tolerate the procedure, or inability of the physician to successfully draw the blood at the time of appointment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in rate of healing in intraoral mucosa and epithelium soft tissues | 3 months post-operatively | Improved healing times of PRF patients compared to control group. |
Outcome results
None listed