Breast Cancer
Conditions
Brief summary
Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients
Interventions
OTHERSpecimen collection
Specimens are obtained from patients who are being treated for breast malignancies.
Sponsors
Ohio State University Comprehensive Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years of age or older * Ability to give informed consent * Stage I-III breast malignancy
Exclusion criteria
* Unable to tolerate venipuncture
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Isolate unfavorable immune cells MDSC from the peripheral blood or tumors of study subjects and test how strongly they inhibit function of favorable immune cells called Natural Killer Cells. | up to 1 year | Function of Natural Killer Cells will be studied by measuring their ability to kill target cancer cells coated with monoclonal antibodies. isolate unfavorable immune cells called Myeloid Derived Suppressor Cells (MDSC) from the peripheral blood or the tumors of study subjects and test how strongly they inhibit function of favorable immune cells called Natural Killer Cells. Function of Natural Killer Cells will be studied by measuring their ability to kill target cancer cells coated with monoclonal antibodies. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Isolate unfavorable immune cells called Myeloid Derived Suppressor Cells (MDSC) from the peripheral blood of study subjects who plan to start pre-operative chemotherapy for breast cancer to see if MDSC levels can predict who will respond to treatment. W | up to 1 year | Percentage of MDSC at baseline and whether there is an association of baseline MDSC percent with response to chemotherapy. |
| Isolate unfavorable immune cells MDSC from peripheral blood of study subjects who receive pre-operative chemotherapy for breast cancer to identify changes in MDSC levels during treatment can predict who will respond to treatment. | up to 1 year | Changes will be reported in percentage of MDSC and associations of such changes with response to chemotherapy. |
| Isolate lymph nodes from patients with breast cancer undergoing breast surgery to study what types of Natural Killer Cells are present. | up to 1 year | Isolate a lymph nodes from patients with breast cancer undergoing breast surgery to study what types of Natural Killer Cells are present. Natural Killer cells are immune cells that are capable of killing cancer cells. |
Countries
United States
Contacts
CONTACTOhio State Comprehensive Cancer Center
PRINCIPAL_INVESTIGATORWilliam Carson, MD
Ohio State Comprehensive Cancer Center
Outcome results
None listed