Endometrial Cancer
Conditions
Keywords
endometrial cancer, circulating tumor cells, laparoscopy
Brief summary
The purpose of this study is to investigate the spread of Circulating Tumor Cells (CTC) during surgery in endometrial cancer. Although this cancer is often discovered at early stage, the risk of recurrence is estimated at 6 to 21%, according to grade. Early stage tumor is accessible for curative surgical treatment by laparoscopy but this kind of surgery may induce CTCs spread, and could be an explanation of this recurrence. Through this study, concordance between two blood punction sites, peripheral vein and ovarian vein, will be evaluated to detect these cells during surgery.
Detailed description
The goal of this single-center clinical trial is to determine the best blood punction site to observe the spreading of CTC during surgery in endometrial cancer. CTCs are very rare events on blood and their detection require extremely sensitive technologies. This pilot study will investigate CTC spread during surgery on 10 patients with endometrial cancer. The main objective is to compare venipuncture site for detection of CTCs in endometrial cancer during surgery. Blood samples are collected on a simple sampling (arm) compared to sampling as close as possible to the tumor (ovarian vein).
Interventions
PROCEDUREblood samples
3 samples: One before surgery on the arm vein (peripheral) Two during the surgery, on two different venipuncture site : * One on the arm vein (peripheral) * One on ovarian vein (close to the tumor) All samples will be tested by the CellSearch method.
Sponsors
University Hospital, Montpellier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Intervention model description
women with endometrial cancer
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with endometrial cancer * Being affiliated or benefiting from a French social security system
Exclusion criteria
* Patients with an other cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Qualitative assessment | During surgery (at the ligature of the ovarian ligament) | Presence or not of at least one CTC during endometrial cancer surgery detected on two venipuncture site (peripheral and ovarian vein). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantitative assessment | Before surgery and during surgery | Number of CTC detected from each sampling |
Countries
France
Outcome results
None listed