FindTrial
Sign In

A Supervised Clinic-to-Community Exercise Intervention to Improve Cardiometabolic Health in Survivors of AYA Cancer

A Supervised Clinic-to-Community Exercise Intervention to Improve Cardiometabolic Health in Survivors of Adolescent and Young Adult Cancer: The ACSEND Trial

Status
Withdrawn
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04021446
Acronym
ASCEND
Enrollment
0
Registered
2019-07-16
Start date
2019-09-30
Completion date
2024-09-30
Last updated
2021-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adolescent Cancer, Body Composition, Cardiometabolic Dysregulation, Young Adult Cancer

Brief summary

The main goal of this clinical trial is to use a novel exercise intervention to improve cardiometabolic and biopsychosocial health outcomes in overweight/obese sedentary survivors of AYA cancers at risk for chronic comorbid conditions. The investigator's hypothesis is that an exercise intervention will improve: cardiometabolic health; body composition; physical fitness and biopsychosocial outcomes when compared to the attention control group.

Interventions

OTHERExercise

personalized exercise prescription

Sponsors

University of Southern California
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 39 Years
Healthy volunteers
No

Inclusion criteria

* AYA cancer survivors (18-39) Must be 12 months after treatment No metastatic disease

Exclusion criteria

* Metastatic disease Pregnancy

Design outcomes

Primary

MeasureTime frameDescription
Cardiometabolic health - Insulin Resistancechange from baseline to 4 months, to 8 months to 1 yearinsulin resistance estimated by HOMA from a fasting blood sample
Cardiometabolic health - metabolic syndrome waist circumferencechange from baseline to 4 months, to 8 months to 1 yearmarkers of metabolic syndrome, waist circumference via measuring tape (cm)
Cardiometabolic health - metabolic syndrome blood pressurechange from baseline to 4 months, to 8 months to 1 yearmarkers of metabolic syndrome, blood pressure via Omron cuff (mmHg)

Secondary

MeasureTime frameDescription
Body Compositionchange from baseline to 4 months, to 8 months to 1 yearfat mass and lean mass via DEXA (reported in lbs)
Cardiorespiratory fitness (Physical Fitness)change from baseline to 4 months, to 8 months to 1 yearcardiorespiratory fitness via submaximal VO2 max (reported via ml/kg/min)
Muscular Strength (Physical Fitness)change from baseline to 4 months, to 8 months to 1 yearmuscle strength through multiple repetition maximum (lbs)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026