Brain Tumor, Pediatric
Conditions
Brief summary
To investigate the effect of radiotherapy on peripheral blood immune cell composition and function in pediatric malignant brain tumor patients.
Interventions
None listed
Sponsors
Capital Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Age from 3 to 18 * To be diagnosed with malignant brain tumors * To eligible for radiation therapy * Karnofsky performance status ≥ 70 * No prior radiation exposure * Informed consent signed for blood sample collection and used for research purpose
Exclusion criteria
* Patients had received radiotherapy previously. * Patients who had no histological diagnosis * Patients who do not wish to participate * Patients with infections
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The changes of peripheral blood immune cells | 6 weeks (prior and post the radiation therapy ) | The flow cytometric analysis of lymphocyte subtypes populations would be performed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Activation status of T cells | 6 weeks (prior and post the radiation therapy ) | Activation status of peripheral IFN-γ-producing effector CD8+ T cells by Elispot. |
| The changs of inflammatory cytokines and chemokines | 6 weeks (prior and post the radiation therapy ) | Human inflammatory cytokines and chemokines will be analyzed by ELISA during radiation therapy. The cytokines and chemokines are IL-2, IL-10, IFN-γ, TNF-α |
Countries
China
Outcome results
None listed