Healthy
Conditions
Keywords
low frequency rTMS, fNIRS, Hemodynamic Response, Non-invasive brain stimulation
Brief summary
In this study, we investigated the effect of low-frequency repetitive trans cranial magnetic stimulation, one of the noninvasive brain stimuli, on the functional changes of the bilateral motor cortical activity in normal subjects using functional near infrared spectroscopy (fNIRS).
Detailed description
In normal subjects, 1. the effect of low-frequency repetitive transcranial magnetic stimulation on cerebral cortex are measured in real time using fNIRS. 2. Changes in cerebral cortical activity before and after stimulation are measured using the motor function test and the motor-induced potential test
Interventions
DEVICElow frequency rTMS + Navigation System
1Hz low-frequency rTMS stimulation over primary motor area using navigation system
DEVICEonly low frequency rTMS
1Hz low-frequency rTMS stimulation over primary motor area
DEVICESham low frequency rTMS + Navigation System
1Hz low-frequency sham rTMS stimulation over primary motor area using navigation system
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
19 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adult men and women without history of central nervous system disease and abnormalities
Exclusion criteria
* Under 18 years old, 70 years old or older * A person who has inserted a metal object in a skull * A person with complete occlusion of the carotid artery * A person with epilepsy * Pregnant and lactating women * Who is not eligible for the test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of Cortical activation | Baseline and after intervention[Immediately after 20 minutes of intervention] | Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) before and after stimulation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in motor evoked potentia | Baseline and after intervention[Immediately after 20 minutes of intervention] | measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle. |
| changes in nine hole peg test | Baseline and after intervention[Immediately after 20 minutes of intervention] | Nine-Hole Peg Test is used to measure finger dexterity in patients with various neurological diagnoses. |
| Sequential motor task | Baseline and after intervention[Immediately after 20 minutes of intervention] | It is a training exercise in which five digits are repeatedly pressed with five fingers using individual movements, and it is trained to press the button accurately and quickly. |
Countries
South Korea
Outcome results
None listed