Impaired Glucose Tolerance, Type2 Diabetes
Conditions
Keywords
Impaired glucose tolerance, type 2 diabetes, obesity, carbohydrate absorption, metformin
Brief summary
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption. It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake. To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.
Interventions
OTHEROral glucose tolerance test (OGTT) with or without metformin
Each participant will have 3 OGTT, one without metformin, one with metformin30 minutes before the test, one with metformin 60 minutes before the test. The order for each test will be randomized.
Sponsors
University Hospital, Lille
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Obesity (BMI ≥30 kg/m2) * Dysglycemia (HbA1c≥ 6,0 %) * No anti diabetic medication
Exclusion criteria
* No obesity (BMI \< 30 kg/m2) * No dysglycemia (HbA1c \<6,0%) * Treatment that might interfere with carbohydrate absorption (anti diabetic medication, antibiotics, probiotics, steroids) * Anemia (Hb \<12 g/dL) * Organ failure * Inflammatory Bowel Disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of D-Xylose | During the 3 hours OGTT |
Secondary
| Measure | Time frame |
|---|---|
| Number of Participants with gastrointestinal side effects | During the 3 hours OGTT |
| Area under the curve of blood glucose | During the 3 hours OGTT |
| Area under the curve of insulin | During the 3 hours OGTT |
| Area under the curve of GLP-1 | During the 3 hours OGTT |
Contacts
PRINCIPAL_INVESTIGATORcamille Marciniak, MD
University Hospital, Lille
Outcome results
None listed