Fracture of Neck of Femur, Knee Osteoarthritis, Lumbar Disc Herniation, Necrosis of Femoral Head
Conditions
Keywords
postoperative cognitive dysfunction, postopeartive delirium, Probiotics
Brief summary
The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.
Interventions
DRUGBifidobacterium triple live capsule
Bifidobacterium triple live capsules, indications for acute and chronic diarrhea and constipation caused by intestinal flora imbalance, can also be used for the treatment of mild to moderate acute diarrhea, chronic diarrhea and indigestion, bloating, and adjuvant treatment of intestinal flora Endotoxemia caused by disorders.
DRUGPlacebos
Placebos were administrated as same as the bifidobacterium live capsule
Sponsors
RenJi Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. . Age is greater than or equal to 65 years old 2. . Can communicate normally 3. . Selective knee ankle, hip replacement or lumbar open reduction and internal fixation under general anesthesia 4. . ASA graded at I-II level 5. . Patient or family informed consent
Exclusion criteria
1. . Have a brain disease, or have a history of brain disease 2. .MMSE check of less than 24 points. 3. . History of neurological and psychological disorders including AD, stroke, psychosis 4. . Serious hearing or visual impairment 5. . Preoperative systolic blood pressure \>190mmhg, or diastolic blood pressure \>100mmhg 6. . The patient or family refuses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of POCD 7days after surgery | The seventh day after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of POCD 1 month after operation | One month after surgery | — |
| Incidence of POD 7 days after surgery | One day after surgery to the seventh day after surgery | Use the CAM scale to assess whether a patient has postoperative delirium |
Countries
China
Contacts
Primary Contacttang ying, Bachelor
Backup Contactsu diansan, Doctor
Outcome results
None listed