Healthy
Conditions
Keywords
diffusing capacity, reliability, healthy, adults, nitric oxide
Brief summary
The measurement of nitric oxide lung diffusing capacity (DLNO) has been recently standardised. To date, two pulmonary function devices are commercially available and are used for the measurement of DLNO. No previous study assessed differences in gas exchange outcomes (e.g., DLNO values) between both devices. The aim of this project is to compare two commercially available devices that measure lung diffusing capacity for nitric oxide (DLNO). 1. MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany 2. HypAir (HA, Medisoft, Dinant, Belgium).
Detailed description
In a single-center, crossover study conducted at the University Hospital Zurich, Switzerland, 35 healthy, non-smoking adults (\>=18 years) will be invited to perform DLNO measurements in random order using the MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium) devices during one study visit. The order of the tests on the MasterscreenTM and HypAir devices will be randomly allocated using central randomisation.
Interventions
DEVICEJaeger Masterscreen TM
Single-breath nitric oxide lung diffusing capacity
DEVICEHypAir Medisoft
Single-breath nitric oxide lung diffusing capacity
Sponsors
University of Zurich
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\- Age 18 years and older
Exclusion criteria
* Previous thoracic surgery * Smoking * Chronic lung disease (e.g., asthma bronchiale, COPD) * Forced expiratory volume in 1s and/or forced vital capacity below the lower limit of normal based on spirometry \[Quanjer et al. Eur Respir J 2005\] * Current respiratory infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in nitric oxide lung diffusing capacity (mL/min/mmHg) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in carbon monoxide lung diffusing capacity (mL/min/mmHg) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in Alveolar volume (L) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in inspiratory volume (L) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in breath-hold time (s) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in inspired concentrations for nitric oxide (in %) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in expired concentrations for helium (%) | 1 day | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in inspired concentrations for carbon monoxide (in %) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in expired concentrations for carbon monoxide (in %) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in inspired concentrations for helium (%) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in inspired concentrations for oxygen (%) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in expired concentrations for oxygen (%) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
| Difference in expired concentrations for nitric oxide (in %) | 1 hour | Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium). |
Countries
Switzerland
Outcome results
None listed