Sepsis, Septic Shock
Conditions
Brief summary
Clarify different causes of sepsis in patients admitted to ICU . as well asCompare causes and outcomes of sepsis between diabetics versus non diabetics . 3.Screening for the commonest organism causing sepsis in critically ill patients. Determine better protocol therapy that help in decreasing mortality and morbidity in patients with sepsis in ICU.
Detailed description
Sepsis is a physiologic, pathologic, and biochemical abnormalities induced by infection. sepsis is considered as a leading cause of mortality and critical illness worldwide by many conservative estimates. sepsis epidemiology studies worldwide revealed a highly variable incidence of 13-300 per 100,000 inhabitants per year for severe sepsis and 11 per 100,000 inhabitants per year for septic shock . factors such as advancing age, immunosuppression and multi-drug-resistant infection play a role in increasing incidence of sepsis during recent decades . patients who survive sepsis often have long-term physical, psychological, and cognitive disabilities with significant health and social implications. Patients with diabetes mellitus have an increased risk of developing infections and sepsis and they constitute 20.1-22.7% of all sepsis patients. Infection also remains an important cause of death in diabetics. The prevalence of diabetes mellitus in Intensive Care Unit patients is as high as 30%, And such patients are at increased risk of experiencing in-hospital Complications, compared to patients without diabetes. Infective complications may be reduced with lower blood glucose concentrations Moreover, in critically ill patients without diabetes, Hyperglycemia is associated with increased mortality, risk of infection, Kidney injury and cardiovascular complications. Moreover, diabetes is a major risk factor for both Acute Kidney Injury and sepsis. Sepsis also is a major cause of Acute Kidney Injury, which develops in one-fourth of all patients with sepsis and half of patients with bacteremia or shock . Sepsis-related Acute Kidney Injury is associated with high mortality rates of up to 70%.
Interventions
DIAGNOSTIC_TESTculture from infected site
ESR ,CRP,CBC, Renal and Liver function will be done on admission and follow up Culture: On admission Urine and blood as well as sputum culture acc. To the cause of infection. Culture from suspected site of infection in catheter related infections.
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
patients admitted to ICU for any reason and devoloped sepsis either on admission or later during thier hospital stay. patients having Criteria of sepsis or septic shock as defined by 3rd consensus guidelines (sepsis 3) ,2016
Exclusion criteria
Previous history of pulmonary problem . Previous history of cardiac disease. Previous history of Autoimmune disease immunocompromised patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| detect the most common organism causing sepsis in ICU . | 20 days | applying culture and sensitivity tests for patients developed sepsis on admission and follow up will direct us to the proper treatment protocol for all patients. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of sepsis in diabetics versus non diabetics in ICU. | 15 days | Asses the effect of hyperglycemia on sepsis outcomes. |
Contacts
Primary ContactHanan Mahmoud, professor
Backup ContactSuhair kassim, PHD
Outcome results
None listed