Healthy, Normal Tension Glaucoma, Open Angle Glaucoma
Conditions
Keywords
glaucoma, retinal blood flow, ocular perfusion pressure
Brief summary
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
Detailed description
According to the World Health Organization (WHO) glaucoma is the second leading cause of blindness. Glaucoma is a global problem, which is becoming even more important as the human life expectancy increases. Although the causes of glaucoma are uncertain, mainly intraocular pression (IOP), genetics, and ocular blood perfusion pressure in the optic nerve determine the cause of the disease. Increasing evidence suggests that in glaucoma patients retinal blood flow is decreased leading to progression and to damage of the optic nerve. In order to measure the peripapillary blood flow a variety of devices using different techniques of flowmetry have been developed. In this study, the reproducibility of the retinal flowmetry measured with the LSFG-NAVI device from Nidek will be investigated. A high reproducibility is crucial for the clinical value of any measuring device.
Interventions
DIAGNOSTIC_TESTLASER SPECKLE FLOWGRAPHY
Non-invasive, real-time imaging and measurement of ocular blood flow of the optic disc and peripapillary region
Sponsors
University of Zurich
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* signed Patient Informed Consent form * Be at least 18 years old * Diagnosis of primary or secondary open-angle glaucoma or normal tension glaucoma or healthy controls
Exclusion criteria
* Age \< 18 years * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * No vulnerable participants will be included in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Coefficients of variation (COV) | 1 month | COVs from 3 measurements of ocular blood flow at visit 1 of observer 1 and at visit 1 of observer 1 and from observer 2 will be computed. |
| intraclass correlation coefficients (ICCs) | 1 month | Intraobserver ICC, interobserver ICC, and inter-session ICC will be computed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cofounder | 1 month | Blood pressure will be checked as potential cofounder |
Countries
Switzerland
Outcome results
None listed