Inflammatory Response
Conditions
Keywords
diaphragm thickness, neutrophil to lymphocyte ratio, mechanical ventilation
Brief summary
A study to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.
Detailed description
Weaning from ventilator sometimes can be failed and it happened due to several factors. One of the causes was Ventilator Induced Diaphragm Dysfunction (VIDD). This VIDD process occurred due to thinning process of the diaphragm thickness or decreased diaphragm muscle mass. The whole process happened due to inflammatory reaction that usually appeared on patients in Intensive Care Unit (ICU). Thus, this study was aimed to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.
Interventions
DIAGNOSTIC_TESTRatio of Neutrophil to Lymphocyte
Each patient was examined for a blood sample of 6 ml of venous blood taken from the cubital vein using a vacuum tube without anticoagulants. Blood samples were centrifuged at a speed of 3500 rpm for 20 minutes. Samples are processed with abbott® devices, to obtain neutrophil and serum lymphocyte levels. Plasma samples are stored in the refrigerator -20 C. The patient's diaphragm thickness was measured on days 0, 3, 5 and then the measurement was compared. Diaphragm thickness was measured in patients using mechanical ventilation in intensive care rooms.
DIAGNOSTIC_TESTLevel of Prealbumin Serum
Each patient was examined for a blood sample of 6 ml of venous blood taken from the cubital vein using a vacuum tube without anticoagulants. Blood samples were centrifuged at a speed of 3500 rpm for 20 minutes. Samples are processed with abbott® devices, to obtain neutrophil and serum lymphocyte levels. Plasma samples are stored in the refrigerator -20 C. The patient's diaphragm thickness was measured on days 0, 3, 5 and then the measurement was compared. Diaphragm thickness was measured in patients using mechanical ventilation in intensive care rooms.
Sponsors
Indonesia University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
17 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Critical patients treated in intensive care unit using mechanical ventilation from day 0. * Patients are clinically predicted to be treated for more than 5 days (qSOFA and clinical assessment)
Exclusion criteria
* History of suffering from neuromuscular disease and or diaphragmatic malformations * Used non-invasive ventilation before starting to use mechanical ventilation * History of tracheostomy * Patients admitted to ICU within 12 months before this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of Prealbumin Serum | 5 days |
| Ratio of Neutrophil to Lymphocyte | 5 days |
Countries
Indonesia
Outcome results
None listed