Acute Kidney Injury, Contrast-induced Nephropathy, Stable Angina
Conditions
Keywords
acute kidney injury, coronary artery disease, contrast-induced acute kidney injury, comorbidity, CI-AKI, stable CAD
Brief summary
Patients aged 18-89 with stable CAD and comorbidities receiving optimal medical treatment requiring PCI with iodinated contrast media. The aim of the study is to assess the prevalence of contrast-induced AKI in 2012-2013 and 2017 cohorts and to evaluate the potential risk factors of CI-AKI to better guide the prevention in patients of higher risk.
Interventions
PROCEDUREIodinated contrast media
Percutaneous coronary intervention with iodinated contest media
Sponsors
I.M. Sechenov First Moscow State Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Inclusion criteria
* Informed consent * Male and female patients 18 y. o. and older * Verified stable coronary artery disease (CAD) * Receiving optimal medical treatment and requiring percutaneous coronary intervention (PCI) with iodinated contrast media
Exclusion criteria
* Pregnancy, lactation * Conditions affecting the prognosis (kidney failure, liver failure, oncology) * Acute coronary syndrome (ACS) * Stroke * Contraindications to PCI * Therapy with nephrotoxic drugs during the enrolment which cannot be stopped * Refusal to sign the informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall mortality | 5 years | — |
| Cardiovascular mortality | 5 years | — |
| Myocardial infarction | 5 years | — |
| Stroke | 5 years | — |
| GI bleeding | 5 years | — |
| CABG | 5 years | CABG after PCI at enrolment |
| PCI | 5 years | Repeat PCI after the enrolment |
Outcome results
None listed