Magnesium Sulfate Causing Adverse Effects in Therapeutic Use, Neuromuscular Blockade
Conditions
Keywords
Magnesium
Brief summary
It is well known that magnesium enhances the effect of neuromuscular blocking agents such as rocuronium. However, it is not known how much magnesium can reduce neuromuscular blocking agents in maintaining deep neuromuscular blockade. Through this study, the investigators will quantitatively analyze the rocuronium saving effect of magnesium.
Detailed description
It is well known that magnesium potentiate the effect of neuromuscular blocking agents. It prolonged the duration of rocuronium and reduces the onset time of rocuronium. Magnesium acts on motor end plate, where magnesium reduces the release of prejunctional acetylcholine, thereby decreasing the muscle membrane excitability. However, the quantitative rocuronium saving effect of magnesium is not clear. This study's hypothesis is that magnesium would reduce the amount of rocuronium. And the investigators want to evaluate how much magnesium can reduce the amount of rocuronium. Secondary outcome is the effects of magnesium on recovery time, postoperative pain, nausea and vomiting.
Interventions
DRUGMagnesium Sulfate
magnesium sulphate 50mg/kg in normal saline 50ml infusion for 10minutes for loading dose followed by 15mg/kg/hr for continuous infusion
DRUGPlacebo
Normal Saline 50ml infusion for loading dose followed by continuous infusion for same dose of magnesium.
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who undergo elective robot assisted radical prostatectomy, between 20 and 80 years with a American Society of Anesthesiologists physical status classification of I or II
Exclusion criteria
* Conduction abnormalities in preoperative EKG such as Atrioventricular block, sinus pause * Glomerular filtration rate \<60ml/min/1.73m2 * Allergy to rocuronium, sugammadex, magnesium * Medications that interfered with muscle activity * Neuromuscular disease * Hypermagnesemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| rocuronium amount | perioperative - until 48hours | total rocuronium/weight/infusion time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| recovery time | perioperative - until 48hours | time from sugammadex injection to Train-of-four ratio 0.9 |
| postoperative pain | at postoperative 30minutes, 6hours, 24hours | 11 point Numerical Rating Scale; 0 (no pain) to 10 (worst imaginable pain), rescue medication |
| postoperative nausea and vomiting | at postoperative 30minutes, 6hours, 24hours | Numerical Rating Scale(0-10), rescue medication |
Countries
South Korea
Outcome results
None listed