Kisspeptin/GPR54 Pathway and Early Puberty

Polymorphisms in the Kisspeptin/GPR54 Pathway Genes and the Risk of Early Puberty

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04012632

Enrollment

628

Registered

2019-07-09

Start date

2016-09-01

Completion date

2019-07-04

Last updated

2019-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Puberty, Precocious

Keywords

SNP, kisspeptin, GPR54

Brief summary

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

Interventions

OTHERthis study was an observational study and no interventions were given to the participants

the participants were recruited and the data as well as blood sample were collected.

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

7 Years to 10 Years

Healthy volunteers

Yes

Inclusion criteria

\- Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion criteria

* The participants who were not the first visit to the hospital and had been treated before. * The participants who were with endocrine disorders.

Design outcomes

Primary

Measure	Time frame	Description
the polymorphism in the KISS1/GPR54 pathway genes	3 months	functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026