Mild Cognitive Impairment
Conditions
Brief summary
Alzheimer's disease (AD) has a detrimental impact on cognitive functions. Based on pilot studies results in patients with neurodegenerative brain diseases the investigators aim for promoting the brain plasticity and improving cognition by noninvasive brain stimulation (NIBS) in healthy young, healthy aged and subjects with mild cognitive impairment due to AD. Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and the more-serious decline of dementia. Different new brain targets, cognitive tasks and stimulation protocols will be tested and optimized for specific subject groups. Design of a functional MRI (fMRI) - repetitive transcranial magnetic stimulation (rTMS) - fMRI study will enable us to explore and identify effect of age, presence of the disease and genetic risk factor (APOE4) on repetitive transcranial magnetic stimulation (rTMS)-induced changes in cognition and related brain connectivity/activations. The study results will improve our understanding of healthy and pathological brain aging and will provide novel information about the usefulness of NIBS in specific subject groups. These results will have an important impact on future non-pharmacological treatment strategies.
Detailed description
Intensified intermittent theta-burst stimulation (iTBS) protocol will be applied in the MCI study group. A two-parallel-group, randomized, placebo controlled design will be used. Ten MCI subjects will be stimulated in a week-long therapeutical sessions. Other ten MCI subjects will be stimulated with the same protocol using sham stimulation. The investigators will study the change in subjects immediately after and again at a two-weeks follow-up visit after the end of the last stimulation session.
Interventions
DEVICETranscranial magnetic stimulation
Transcranial magnetic stimulation device will be used. Short protocol iTBS will be applied.
Sponsors
St. Anne's University Hospital Brno, Czech Republic
Masaryk University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* amnestic single or multi-domain mild cognitive impairment patients in accordance with diagnostic criteria (Albert et al., 2011)
Exclusion criteria
psychiatric disorders, including major depression, major vascular lesions, and other brain pathologies detected by MRI that might present with cognitive decline * a cardio pacemaker or any MRI-incompatible metal in the body * epilepsy * any diagnosed psychiatric disorder * alcohol/drug abuse * lack of cooperation * presence of dementia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual-attention task accuracy and reaction times | On the beginning of the study, after completion of week stimulation a two weeks after completion of stimulation sessions. | Stroop task will be presented in fMRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resting state measurement | On the beginning of the study, after completion of week stimulation a two weeks after completion of stimulation sessions. | The effect of stimulation on the resting state networks will be studied using fMRI measurement. |
Countries
Czechia
Contacts
Primary ContactLubomira Anderkova, PhD
Outcome results
None listed