Hepatocellular Carcinoma, Liver Cirrhosis, Liver Steatosis, Magnetic Resonance Imaging, Pancreatic Cancer
Conditions
Keywords
liver, cirrhosis, steatosis, hepatocellular carcinoma, pancreatic cancer, 7 tesla, magnetic resonance imaging
Brief summary
Aim of this study is to evaluate the correlation between the characteristics detected by the 7T MRI equipment and the histological composition of native explanted livers (group A), liver graft excluded for donation (group B) and surgical specimens of primary pancreatic tumour, which underwent pancreaticoduodenectomy (group C).
Interventions
DIAGNOSTIC_TEST7T Magnetic Resonance Imaging
* T1-weighted and T2-weighted sequences * quantitative magnetic resonance imaging approach * proton spectrum analyses
Sponsors
Azienda Ospedaliero, Universitaria Pisana
Imago 7
University of Pisa
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Three single groups to be included
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
GROUP A of Native Liver Inclusion Criteria: * informed consent * full possession of one's faculties * patients who are going to undergo liver transplantation, independently from previous therapy or from the primary disease they are affected by.
Exclusion criteria
* patients affected by polycystic liver disease * excluded from liver transplantation. GROUP B of Excluded Grafts Inclusion Criteria: \- liver grafts with histologically proven macrovescic steatosis, not fit for transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the correlation between the characteristics detected by the MRI equipment and the histological composition of ex-vivo specimens from hepatic and pancreatic tissues and lesions | 3 years | The creation of a data-bank will increase the knowledge about imaging features able to characterize many diseases affecting the liver, and to evaluate cell changes that occur in pancreatic cancer and the tumour pathways of spreading; moreover it will provide a reference framework to define proper acquisition protocols for future clinical applications. Such data will also provide imaging biomarkers of malignant cells, and show the morphological changes that occur in neoplastic lesions after systemic or loco-regional therapies. |
Countries
Italy
Contacts
Primary ContactLaura Crocetti, MD,PhD
Backup ContactRosa Cervelli, MD
Outcome results
None listed