Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples

Sex-specific Relationship of Epigenetics Based Modifications in the Saliva and Blood With the Occurence of Type 2 Diabetes

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04011228

Enrollment

224

Registered

2019-07-08

Start date

2016-02-29

Completion date

2020-01-01

Last updated

2019-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Type 2, Ectopic Lipids, Epigenetics Based Modifications, Prediabetic State

Brief summary

The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.

Interventions

DIAGNOSTIC_TESTBlood sampling

After a fasting period over night blood samples will be taken.

DIAGNOSTIC_TESTSaliva and blood samples

After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.

DIAGNOSTIC_TESTMagnet Resonance Spectroscopy

The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Inclusion criteria

* type 2 diabetic patients * prediabetic patients * women with gestational diabetes * healthy control subjects without diabetes * healthy pregnant women

Exclusion criteria

* cancer disease * infectious diseases such as hepatitis or HIV * malignoms * patients with claustrophoby

Design outcomes

Primary

Measure	Time frame	Description
Specifying the microRNAs in saliva in diabetic patients	1 hour	Characterization of microRNAs in saliva of prediabetic and type 2 diabetic patients, as well as in women with gestational diabetes and healthy control subjects.

Secondary

Measure	Time frame	Description
Correlation of the percentage of liver fat with miRNA´s in diabetic patients.	1 hours	Correlation of miRNA´s in the saliva with the amount of intrahepatic liver fat.
Correlation of the percentage of heart fat with miRNA´s in diabetic patients	1 hour	Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the heart.
Correlation of the percentage of the content of fat in the skeletal muscle with miRNA´s in diabetic patients.	1 hour	Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the skeletal muscle.

Countries

Austria

Contacts

Primary ContactAlexandra Kautzky-Willer, Univ.Prof.Dr.

alexandra.kautzky-willer@meduniwien.ac.at+434040021260

Backup ContactMichael Leutner, Dr.med.univ., MSc

michael.leutner@meduniwien.ac.at

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026