Iodine Status Monitoring in PortUguese Pregnant woMen: Impact of Supplementation

Conditions

Iodine Deficiency, Iodine Status in Pregnancy

Brief summary

Data from 2007 regarding iodine status among Portuguese pregnant women indicate this is an iodine deficient population group, with only 16.8% presenting adequate urinary iodine values. This may have serious implications for normal cognitive development of the offspring and a concerning socioeconomic impact. In 2013, concerns by the Portuguese Directorate-General of Health lead to the implementation of a public health policy (nº 011/2013) recommending iodine supplementation during pregnancy. IoMum emerges from this context to monitor and update iodine status in Portuguese pregnant women and to evaluate the effectiveness of the above policy by assessing clinical compliance to iodine supplementation and the impact of iodine supplementation in this vulnerable group. IoMum will update data on iodine nutrition in Portuguese pregnant women, promoting political actions towards the elimination of iodine deficiency and thus to the reduction of nutritional, social and economic inequalities.

Isabella Bracchi, Juliana Guimarães, Catarina Rodrigues, Rui Azevedo, Cláudia Matta-Coelho et al. (22 authors)

Biology2023-10-216 citations

10.3390/biology12101351

Noncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in Portuguese pregnant women: results from the IoMum cohort.

Matta Coelho C, Guimarães J, Bracchi I, Xavier Moreira N, Pinheiro C, Ferreira P, Pestana D, Barreiros Mota I, Cortez A, Prucha C, Martins C, Pinto E, Almeida A, Delerue-Matos C, Dias CC, Moreira-Rosário A, Ribeiro de Azevedo LF, Cruz Fernandes V, Ramalho C, Calhau C, Brantsæter AL, Costa Leite J, Keating E.

2022-05-305 citations

10.1007/s40618-022-01813-7

Interventions

DIAGNOSTIC_TESTUrinary Iodine Concentration Measurement

UIC

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Yes

Inclusion criteria

* Pregnant women attending the 1st trimester fetal ultrasound scan, from the 10th to the 13th gestational week.

Exclusion criteria

* Use of Levothyroxine.

Design outcomes

Primary

Measure	Time frame	Description
1st trimester urinary iodine concentration	Between gestational weeks 10 and 13 plus 6 days (one timepoint collection - Timepoint 1)	Median urinary iodine concentration at 1st trimester of gestation
Rate of compliance to iodine supplementation guideline	Between gestational weeks 10 and 13 plus 6 days (one timepoint collection - Timepoint 1)	Rate of compliance to iodine supplementation guideline at 1st trimester of gestation

Secondary

Measure	Time frame	Description
Maternal median thyroglobulin	Between gestational weeks 35 and 41 (one timepoint collection - Timepoint 2)	Maternal median thyroglobulin at 3rd trimester of gestation
Change in median iodine-to-creatinine ratio	Up to 31 weeks	Change in median iodine-to-creatinine ratio between 1st and 3rd trimesters of gestation
3rd trimester mean sodium excretion	Between gestational weeks 35 and 41 (one timepoint collection - Timepoint 2)	Mean sodium excretion at 3rd trimester of gestation
1st trimester mean sodium excretion	Between gestational weeks 10 and 13 plus 6 days (one timepoint collection - Timepoint 1)	Mean sodium excretion at 1st trimester of gestation
Proportion of pregnant women with insufficient, adequate or excessive iodine intake	Between gestational weeks 10 and 13 plus 6 days (one timepoint collection - Timepoint 1)	Classification of pregnant women by urinary iodine concentration levels according to WHO criteria (insufficient, adequate or excessive iodine intake) at 1st trimester of gestation.

Countries

Portugal

Outcome results

None listed