A Registered Cohort Study on Brain Calcification

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04010201

Enrollment

2000

Registered

2019-07-08

Start date

2019-08-25

Completion date

2079-12-31

Last updated

2019-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Calcification

Keywords

brain calcification, natural history, genetics

Brief summary

Brain calcification is a common neuroimaging feature in patients with metabolic, neurological, or developmental disorders, infectious diseases, traumatic or toxic history, as well as in otherwise normal older people. To understand the clinical and genetic characteristics of brain calcification, we establish a cohort of brain calcification to follow up patients with brain calcification.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Patients with brain calcium deposit(s) based on examinations of CT scans * Patients with total calcification score(TCS) greater than the physiological threshold * Relatives of brain calcification patients. * Unrelated healthy controls * Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process

Exclusion criteria

* Brain calcification caused by specific secondary factors such as infection, poisoning, and trauma * Participants declining or unable to comply with trial procedures and visit schedule

Design outcomes

Primary

Measure	Time frame	Description
The incidence of hereditary brain calcification	Up to 20 years	Look for the causative gene in the patient with brian calcification

Countries

China

Contacts

Primary ContactYi Lin, PhD

linyi7811@163.com86-0591-87982772

Backup ContactWan-Jin Chen, PhD

wanjinchen75@fjmu.edu.cn86-0591-87982772

Outcome results