Electroencephalogram, Music, Near-infrared Spectroscopy, Preterm Infant
Conditions
Brief summary
Music has been consistently shown magic power in brain plasticity. Several study proved music can influence electronic activity of preterm infants' brain, while none study covered region oxygen metabolic. The investigators aim to discover the effects of music therapy on near-infrared spectroscopy and electroencephalogram in premature infants.
Detailed description
Previous studies of music therapy have made some achievements for adult Parkinson's disease, schizophrenia, depression, anxiety, post-traumatic stress and pediatric autism spectrum disorders. For newborns, studies mainly focused on the effects of basic vital signs, feeding and pain score decreasing. So far, no studies evaluating the effect of music therapy on brain oxygen metabolic and electronic activity.
Interventions
OTHERmusic
music selected by musician
Sponsors
Children's Hospital of Fudan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
224 Days to 258 Days
Healthy volunteers
No
Inclusion criteria
* Postmenstrual age of 32-36+6 weeks. * Appropriate weight for gestational age. * To have signed an informed consent to participate in the study. * Have reached clinical stability.
Exclusion criteria
* Have nervous system diseases or obvious nervous system symptoms. * Severe congenital diseases. * The maintenance of sedative or analgesic drugs. * Support with mechanical ventilation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of brain oxygen saturation | from the start of the intervention to the end of the 3rd day | near-infrared spectroscopy to monitor brain oxygen saturation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Burdjalov Scores of amplitude integrated electroencephalogram | from the start of the intervention to the end of the 3rd day | electroencephalogram to monitor brain electronic activity, using Burdjalov developed cerebral function monitoring scoring system which including: (1)record continuity: assessed through observing the overall density of the sample tracing, scores ranged from 0 to 2；(2) presence of cyclic changes：refers to the emergence and progression of periods during monitoring，scores ranged from 0 to 5；（3）degree of voltage amplitude depression：estimated as the average lower microvolt level during the recording epoch ，scores ranged from 0 to 2；（4）bandwidth：reflects a combination of the voltage span (peak-to-trough) of the tracing and the magnitude of the electroencephalogram depression，scores ranged from 0 to 4. The minimum possible total score was 0, and the maximum was 13. Scores progressively increased with central nerve system maturation. |
| change of heart rates | from the start of the intervention to the end of the 3rd day | monitors recording heart rates |
| change of respiratory rates | from the start of the intervention to the end of the 3rd day | monitors recording respiratory rates |
| change of pluse oxygen saturation | from the start of the intervention to the end of the 3rd day | monitors recording transcutaneous oxygen saturation |
Countries
China
Outcome results
None listed