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Effect of Date Seeds Coffee on Mood and Cognitive Performance

Investigating the Acute Effects of Mood and Cognitive Performance Following the Administration of a Coffee Made of Date Seeds on Healthy Young Volunteers.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04009564
Enrollment
52
Registered
2019-07-05
Start date
2019-06-20
Completion date
2020-03-30
Last updated
2020-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Status

Brief summary

Limited utilizations of date seeds have previously been explored, and so previously wastage has often been the normality. However, research now indicates that several fruit seeds contain higher concentrations of beneficial total phytochemicals within their seeds in comparison to the flesh. As well as high nutritional values of date seeds for fibre, protein and micronutrients, this increased phytochemical content has been proven to be true for date seeds, with mainly phenolic acids (24.6 g k GAE) 3 and total flavonoids (3.67 g k RE). With the seeds presently being used to produce new coffee products, it raises questions on whether consumption of date seeds can alter mood and cognitive behaviour and therefore research into investigate the acute effect of date seeds coffee on mood and cognitive function on healthy young volunteers. However, to the best of the research team knowledge, this is the first human trial to investigate these effects.

Detailed description

Introduction Seeds of the date palm (P. dactylifera) are a very rich source of bioactive compounds, thus constituting strong candidates for functional food additives and nutraceuticals. Many promising results were observed when the effect of date flesh and seeds consumption have been studied in animals, for their role as either a protective1 against neurodegenerative 2,4,5 diseases, or as a cure for it 2. Most of the observed effects were attributed to the antioxidant and anti-inflammatory properties in dates flesh and seeds fruit due to it high content of phenolic compounds 3. Rational For years, date seeds were considered a waste, having no other uses except for feeding animals. However, as has already been demonstrated in other fruits and corresponding seeds, total phytochemical content of the date seeds was higher than in the edible flesh9. Date seeds have also been shown to have an excellent nutritional quality due to high amounts of fibre (676-742 g/kg) 3 depending on variety, considerable amounts of minerals, vitamins, lipids and protein. Additionally, date seeds were shown to be rich in antioxidants containing mainly phenolic acids (24.6 g k Gallic Acid equivalent) 3 and total flavonoids (3.67 g k Rutin Equivalent). Nowadays, and on sight of the aforementioned findings, date seeds are used to make a new coffee product. This ''coffee alternative'' is commercially available and is becoming more popular. Although, many studies have demonstrated that date seeds possess high antioxidant activities, due to their high content of flavonoids and phenolic compounds, no human trial has investigated the effect of the consumption of date seeds on humans and especially on mood and cognitive behaviour. Therefore, this study, for the first time, to the best of the research team knowledge will investigate the acute effect of date seeds coffee on mood and cognitive function on healthy young volunteers. Aim The aim of this study is to investigate the acute effects of a coffee made of date seeds on mood and cognitive performance.

Interventions

DIETARY_SUPPLEMENTDate coffee

45 g of date seeds coffee in 280 ml of water

DIETARY_SUPPLEMENTNormal coffee

6 g of normal coffee in 280ml of water

DIETARY_SUPPLEMENTPlacebo

water, food colouring and coffee flavouring

Sponsors

Newcastle University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy young volunteers age between 18 to 35

Exclusion criteria

Participants will be ineligible to participate in the study if any of the following apply: 1. Have a BMI above 35kg/m2 2. Smokers or tobacco product consumers which includes electronic cigarettes 3. Are taking any illicit or prescribed drugs. 4. Have a history of, or currently, abuse alcohol 5. Have a history of dyslexia, ADHD, learning difficulties or colour blindness, 6. Females who are pregnant, lactating or seeking to become pregnant, or are at risk of pregnancy as they to do not use birth control measures 7. Have allergies to any food product.

Design outcomes

Primary

MeasureTime frameDescription
The average of the change in 9 cognitive indexes including: Attentional Intensity, Sustained Attention, Attentional Fluctuation, Memory Retrieval Speed, Cognitive Reaction Time, Working Memory Capacity, Episodic Memory Capacity, Quality of MemoryChange from baseline at 45 minutes post dose and at 90 minutes post dose for each visitCog-track an online set of nine cognitive tests (www.wesnes.com).

Secondary

MeasureTime frameDescription
Change in Caffeine consumption using caffeine consumption questionnaireChange form Baseline for each visit onlyA paper based questionnaire developed by Erika Bühler et al., 2014. At the screening visit and on each study day participants will be asked to complete the table in order to build a picture of their individual caffeine habits
Caffeine research Visual Analogue ScalesChange from baseline 45 minutes post dose and at 90 minutes post dose.A caffeine research Visual Analogue Scales which comprises of 7 scales (relaxed, alert, jittery, tired, tense, headache and overall mood).
Change in Mood using Bond Lader Visual Analogue ScalesChange from baseline 45 minutes post dose and at 90 minutes post dose.This widely used set of 16 100 mm VASs yields three extensively validated factor scores: alertness, calmness and contentment.

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026