Neonatal Meningitis
Conditions
Keywords
meningitis, epidemiology, neonate, newborn
Brief summary
Meningitis, defined as inflammation of the meninges caused by different pathogens, is a serious infection associated with high morbidity and mortality. It occurs more commonly in the neonatal period than in any other age group. Neonatal meningitis is a devastating infection that occurs more commonly in neonates than in any other age group, and is associated with significant morbidity and mortality. In this study, we aimed to evaluate epidemiology, treatment and prognosis of neonatal meningitis in a large-scale retrospective multicenter cohort study. The main objectives of this study were to assess the incidence, temporal trend, risk factors, causative organisms, and short term outcomes of neonatal meningitis in a large national cohort of newborn infants admitted to Turkey NICUs.
Interventions
None listed
Sponsors
Zekai Tahir Burak Women's Health Research and Education Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 30 Days
Healthy volunteers
No
Inclusion criteria
* Subject has a positive cerebrospinal fluid culture/PCR of bacterial pathogen. * Subject has a positive blood culture of bacterial pathogen and counts of white blood cells in cerebrospinal fluid ≥20 /mm3.
Exclusion criteria
* Major congenital anomalies * Cultures positive for coagulase-negative staphylococci (CONS) were excluded as possible contaminants, if not clinically and laboratory compatible with meningitis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of neonatal meningitis | average of 5 years | Occurrence of a meningitis in NICU within a specified period of time. (Number of neonatal meningitis cases / Total number of inpatients in the study period) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Causative organisms | average of 5 years | Number and types of isolated microorganisms in CSF cultures |
| Neurodevelopmental Outcome | 18 to 24 months | \- Bayley Scales of Infant Development, Second Edition (BSID II), was performed a comprehensive assessment including neurological and developmental evaluation. The mean BSID II score is 100 for Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI), with a standard deviation (SD) of 15; a score of less than 70 (42 SDs below the mean) indicates a significant delay. Infants who were so severely impaired that testing with the BSID II could not be performed were assigned a MDI and PDI score of 49. |
| Mortality | up to 28 days | Neonatal meningitis related mortality |
Countries
Turkey (Türkiye)
Contacts
Primary ContactMehmet Yekta Oncel, M.D.
Backup ContactEda Karadag Oncel, M.D.
Outcome results
None listed