Aging, Aged Garlic, Vascular Function and Muscle Oxygenation

Effect of Aged Garlic on Vascular Function and Muscle Oxygenation Responses in the Elderly

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04008693

Enrollment

Registered

2019-07-05

Start date

2019-08-26

Completion date

2020-03-30

Last updated

2020-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Obesity, Aging, Dyslipidemias, Hypertension

Keywords

Aging, Aged Garlic, Functional Food, Vascular Function, Muscle oxygenation, Exercise performance

Brief summary

The number of elderly individuals affected by cardiovascular diseases has been increasing in our country. Garlic (Allium sativum) has been associated with decrease of reactive species of oxygen, hypertension, high cholesterol, platelet aggregation, blood coagulation and especially cardiovascular diseases. The present study evaluated the effects of a garlic supplementation on vascular function and blood pressure in the elderly at cardiometabolic risk. Twenty-eight elderly individuals were submitted to an ingestion of four capsules of an aged garlic extract (KYOLIC® Aged Garlic Extract™). Muscle oxygenation and function were measured 180 min after interventions. Urinary thiosulfate, blood nitrate, nitrite, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at baseline and 180 min after interventions.

Interventions

DIETARY_SUPPLEMENTAged Garlic Extract

2.400 mg (four capsules) of a nutritional supplement of aged garlic extract (Kyolic® Hi-Po Formula - Kyolic)

OTHERPlacebo

800 mg of maltodextrin (four capsules)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

60 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Cardiometabolic risks * Cardiovascular diseases

Exclusion criteria

* Cancer; * HIV positive; * Alcohol or drug abuse within the past 6 months previous the visit 1; * Garlic allergy;

Design outcomes

Primary

Measure	Time frame	Description
Near infrared spectroscopy 1	180 minutes after nutritional intervention	microvascular endothelial function
High performance liquid chromatography 1	Baseline and 180 minutes after nutritional intervention	Urinary nitrate concentrations
High performance liquid chromatography 2	Baseline and 180 minutes after nutritional intervention	Urinary thiosulfate concetrations
Near infrared spectroscopy 2	180 minutes after nutritional intervention	muscle oxygenation saturated assessment

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 18, 2026