Cancer of Abdomen, Cancer of Pancreas, Cancer of Pelvis, Cancer of Thorax
Conditions
Brief summary
The investigators propose here to evaluate the feasibility of a novel cone-beam CT (CBCT)-guided online adaptive radiotherapy (ART) workflow on the Halcyon device.
Interventions
DEVICERing gantry kV-CBCT combined with linear accelerator
Each imaging session will be less than one hour, and is expected to take no more than 15 minutes.
Sponsors
Varian Medical Systems
Washington University School of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* At least one disease site deemed to be suitable for simulated treatment with online adaptive radiotherapy per radiation oncology evaluation. * Scheduled to receive radiation therapy to the thorax (n = 8), pancreas (n = 8), non-pancreas abdomen (n = 8), or pelvis (n = 8). * At least 18 years of age * Able to understand and willing to sign an IRB-approved written informed consent document.
Exclusion criteria
* Pregnant and/or breastfeeding. Women of childbearing potential must have a negative pregnancy test within 14 days of study entry. If pregnancy test is not clinically indicated as determined by treating physician or protocol PI, documentation of this exception is sufficient in lieu of a pregnancy test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of the device as measured by successful completion of the full CBCT-guided online ART workflow, from volumetric imaging through phantom delivery in at least 90% of attempted fractions | Completion of ART workflow in all enrolled participants (estimated to be 30 months) |
Countries
United States
Outcome results
None listed