Bacteremia
Conditions
Brief summary
This is an prospective observational study assessing the effect of vitamin B12 on the odds of developing sepsis in patients with infection confirmed by a positive culture result. The hypothesis is that patients with infection confirmed by positive cultures who develop sepsis have lower vitamin B12 levels than patients infection, confirmed by positive cultures, who do not develop sepsis.
Interventions
None listed
Sponsors
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults (≥18 years old) * Infection, confirmed by a positive culture result * Signed informed consent.
Exclusion criteria
* Pregnancy and/or breast feeding * Inability to follow the procedures of the study, due to language problems, psychological disorders, social conditions or dementia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Holotranscobalamin (HTC) levels | 6 days | HTC levels in patients with infection and sepsis compared to patients with infection without sepsis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vitamin B12 levels | 6 days | Levels of vitamin B12 in patients with infection and sepsis compared to patients with infection without sepsis |
| Methylmalonic acid (MMA) levels | 6 days | Levels of ethylmalonic acid (MMA) in patients with infection and sepsis compared to patients with infection without sepsis |
Countries
Switzerland
Outcome results
None listed