Amyotrophic Lateral Sclerosis
Conditions
Keywords
amyotrophic lateral sclerosis, natural history, genetics, prognostic factors
Brief summary
Amyotrophic lateral sclerosis (ALS) is a kind of motor neuron degeneration disorder without effective therapy. This registered cohort study will provide further insights into the clinical course of ALS, and investigate disease-relative risk factors and the genetic background of Chinese ALS patients.
Detailed description
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), which is characterized with highly clinical heterogeneity and no effective treatment is available now. The purpose of this registered cohort is to observe the natural history of ALS patients in China, and then identify some factors correlated with disease progression. Besides, ALS-related gene mutations will be screened and explore novel disease causing gene as well.
Interventions
None listed
Sponsors
First Affiliated Hospital of Fujian Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Amyotrophic Lateral Sclerosis patients fulfilling the El Escorial criteria (including definite, probable and possible) * Progressive muscular atrophy * Primary lateral sclerosis * Progressive bulbar palsy
Exclusion criteria
* History of serious head trauma or neuropsychiatric disease * Decline to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Age at death | 10 years | the time when patient die |
| Age of endotracheal intubation or tracheotomy | 10 years | the time for the patient accepted endotracheal intubation or tracheotomy |
Countries
China
Contacts
Primary ContactQi-Jie Zhang, PhD
Outcome results
None listed