Inflammation, Muscle Mass, Regeneration Muscle
Conditions
Keywords
protein bar, physical activity, muscle
Brief summary
Post-exercise nutrition is an important factor in a nutrition plan for physically active subjects. Focusing on that, the Serbian group is developing protein bars enriched with sports supplements. Slovenian partner group will investigate the effect of new protein bar consumption on body composition, biochemical parameters, and muscle regeneration after training. The new bar will be compared with a commercially available bar.
Detailed description
The clinical study will be performed on 10 elite handball players from Slovenia handball club. It will be designed as a crossover study. Half of the participants will consume the new bar for five days and the other half will consume the control bar. After the five-day washout period, the groups will consume the bar which was not consumed in the first period. At baseline, at the end of every intervention and washout period, the blood samples will be withdrawn, and the body composition will be analyzed. The analyzed biochemical parameters will be basic serum parameters, such as fasting glucose, total cholesterol, LDL, HDL, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), C-reactive protein (CRP), and parameters related to the muscle regeneration and inflammation, such as creatine kinase, lactate dehydrogenase, insulin-like growth factor (IGF), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1). In the second part of the study, the acute effect of consuming each bar after training will be tested. Each participant will consume both bars on separate days. The mentioned parameters will be assessed after training and immediately and 3h after bar consumption.
Interventions
DIETARY_SUPPLEMENTDrRip - high protein, high fibre and creatine load
A protein bar or control bar consumption after training every day for 5 days, 5 days wash-out, 5 days second bar consumption
DIETARY_SUPPLEMENTVoltage energy bar
A protein bar or control bar consumption after training every day for 5 days, 5 days wash-out, 5 days second bar consumption
Sponsors
Zala Jenko Praznikar
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* daily high-intensity physical activity
Exclusion criteria
* smoking, cardiovascular, neurological, skeletal muscle disease, allergies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle mass | 15 days | Muscle mass in kilograms will be determined using bioelectrical impedance analysis (BIA). |
| Fat mass | 15 days | Fat mass in kilograms will be determined using bioelectrical impedance analysis (BIA). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| C-reactive protein | 15 days | Serum levels of C-reactive protein (parameter of inflammation) will be analyzed by biochemistry analyzer (Cobass c111). |
| Creatine kinase | 15 days | Serum levels of creatine kinase (marker of regeneration) will be analyzed by biochemistry analyzer (Cobass c111). |
| Lactate dehydrogenase | 15 days | Serum levels of creatine kinase (marker of regeneration) will be analyzed by biochemistry analyzer (Cobass c111). |
| Tumor necrosis factor alpha | 15 days | Serum levels of Tumor necrosis factor alpha (parameter of inflammation) will be analyzed by enzyme linked immunosorbent assays (ELISA). |
Countries
Slovenia
Outcome results
None listed