Lung Cancer
Conditions
Brief summary
Unlike conventional thoracic surgery performed under general anesthesia with tracheal intubation, non-intubated thoracic surgery with sedation and regional anesthesia has been performed recently. Non-intubated thoracic surgery is expected to reduce the postoperative inflammatory changes by maintaining more physiologic status during the operation compared to intubated thoracic surgery. The aim of this study was to compare perioperative immunological changes between intubated and non-intubated thoracic surgery.
Interventions
OTHERVentilation method
Depending on the group assignment, mechanical ventilation or spontaneous breathing was performed.
Sponsors
The Catholic University of Korea
Seoul St. Mary's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\ II
Exclusion criteria
* preoperative inflammation (CRP\>10ng/㎖, WBC\>10,000/mm3, body temperature \>38℃) * steroid administration within 1 month * hematologic / autoimmune disease * congestive heart failure (NYHA class III\ IV) or significant arrhythmia * severe obstructive / restrictive pulmonary disease * previous history of thoracic surgery * BMI \>28kg/m2 * expected difficult airway
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Interleukin (IL)-6 | 24 hours after surgery | Blood samples collected from the antecubital vein |
Countries
South Korea
Outcome results
None listed