Lung Cancer
Conditions
Brief summary
The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.
Interventions
DRUGDexmedetomidine
The study drug for each group was administered from the time immediately after induction of anesthesia until the end of the surgery.
Sponsors
Seoul St. Mary's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\ II
Exclusion criteria
* preoperative inflammation (CRP\>10ng/#, WBC\>10,000/mm3, body temperature \>38#) * steroid administration within 1 month * hematologic / autoimmune disease * congestive heart failure (NYHA class III\ IV) or significant arrhythmia * severe obstructive / restrictive pulmonary disease * previous history of thoracic surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Interleukin (IL)-6 | 24 hours after surgery | Blood samples were collected from the antecubital vein |
Countries
South Korea
Outcome results
None listed