Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

A Review of Meta-Analyses on Bioavailable Stannous Fluoride Dentifrices: Effects on Dental Plaque

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04006483

Enrollment

2359

Registered

2019-07-05

Start date

2018-01-08

Completion date

2018-11-30

Last updated

2023-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Plaque

Brief summary

The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on dental plaque relative to a positive or negative control dentifrice.

Interventions

DRUGStannous fluoride dentifrice

Stannous fluoride (0.454%) dentifrice

DRUGPositive control dentifrice

Positive control dentifrice containing (0.3%) triclosan.

DRUGNegative control dentifrice

Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%)

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

Subjects were excluded from this study for the following reasons; * pregnancy, * rampant caries, * severe periodontitis, * at discretionary of the Principal Investigator.

Design outcomes

Primary

Measure	Time frame	Description
Dental Plaque Scores	Up to 12 weeks	Change from baseline as measured by mean plaque score reduction from baseline (via Quigley-Hein, Turesky Modification Index or Rustogi Modification of the Navy Plaque index).

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026