Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion

Bioavailable Stannous Fluoride Dentifrice Meta-Analyses: Effects on Dentine Hypersensitivity and Enamel Erosion

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04006470

Enrollment

172

Registered

2019-07-05

Start date

2018-01-08

Completion date

2018-11-30

Last updated

2019-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enamel Erosion

Brief summary

The aim of this 5 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices to assess enamel erosion protection in-situ using surface profilometry.

Interventions

DRUGStannous fluoride dentifrice

Stannous fluoride (0.454%) dentifrice

DRUGPositive control dentifrice

Positive control dentifrice containing potassium nitrate or arginine.

DRUGNegative control dentifrice

Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%)

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* healthy subjects

Design outcomes

Primary

Measure	Time frame	Description
Change from Baseline Surface profilometry	10 days	Enamel samples will be measured via profilometry after 10 days of study use.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026