Spastic Paraplegia
Conditions
Brief summary
The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias(HSP) and related disorders in a prospective multicenter natural history study, to assess the clinical, genetic and epigenetic features of patients with Spastic Paraplegias to optimize clinicalmanagement..
Interventions
None listed
Sponsors
Wan-Jin Chen
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with the clinical diagnosis of spastic paraplegia * Clinical diagnosis of patients with spastic paraplegia * Unrelated healthy controls
Exclusion criteria
* Decline to participate. * There are serious interferences with individual participation and adherence to the research protocol, including but not limited to neurological, psychological, and/or medical conditions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spastic Paraplegia Rating Scale (SPRS) | 6 months | Disease severity will be assessed by application of the Spastic Paraplegia Rating Scale (SPRS), a clinical rating scale measuring disease severity in Hereditary Spastic Paraplegia (Schule et al. Neurology 2006). The SPRS contains 13 items, each ranging from 0 to 4 points. The total score is calculated as the sum of all items, yielding a range for the total score between 0 and 52. Hereby, higher SPRS total scores indicate more severe disease. |
Countries
China
Contacts
Primary ContactYi Lin, MD,PhD
Backup ContactWan-Jin Chen, MD,PhD
Outcome results
None listed