The Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Lipid Profile Levels and Oxidized Low Density Lipoprotein

Assessing the Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Lipid Profile Levels and Oxidized Low Density Lipoprotein: a Randomized Controlled Trial in Males and Females With Vitamin D Deficiency

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04005573

Enrollment

111

Registered

2019-07-02

Start date

2019-07-10

Completion date

2020-01-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D Deficiency

Keywords

vitamin D3, Vitamin D Deficiency, Lipid profile, oxidized low density Lipoprotein, omega-3 fatty acids

Brief summary

The combined effect of omega-3 fatty acid and vitamin D3 on lipid profile levels and oxidized low density lipoprotein: a randomized controlled trial in males and females with vitamin D deficiency

Detailed description

Nothing is published in the literature about the combined effect of vitamin D3 (VD3) and omega-3 fatty acids (omega-3FA) on on lipid profile levels and oxidized low density lipoprotein This study will be conducted to investigate effect of VD3 and omega-3FA alone and with each other on lipid profile levels and oxidized low density lipoprotein in Jordanian people with vitamin D deficiency. This randomized, controlled clinical trial will be designed to test effects of 50,000 IU VD3 weekly and 300 mg omega-3FA daily for eight weeks, separately and with each other, on on lipid profile levels and oxidized low density lipoprotein

Interventions

DIETARY_SUPPLEMENTomega 3- FA

Omega 3 FA group 300 mg once daily for 8 weeks

DIETARY_SUPPLEMENTVD3 and omega- 3FA

50000 IU VD3/week for 8 weeks and 300 mg of omega- 3 FA once daily for 8 weeks

DIETARY_SUPPLEMENTVD3

VD3 50000 IU/ week for 8 weeks

OTHERno intervention

no intervention is given

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

22 Years to 64 Years

Healthy volunteers

Yes

Inclusion criteria

* Jordanian people aged 25-55 medical diagnosis of vitamin D deficiency ( VD \<25 ng/ ml)

Exclusion criteria

* Subjects with previously diagnosed with any chronic disease (cardiovascular disease, osteoporosis, cancer, kidney disease, endocrine disorder, thalassemia) or has a documented history of allergic reactions to n-3FA supplementations

Design outcomes

Primary

Measure	Time frame	Description
oxidized LDL	8 weeks	serum level of oxidized LDL
LDL Cholesterol	8 weeks	serum level of LDL Cholesterol
triglycerides	8 weeks	serum level of triglycerides
VD 3	8 weeks	Serum level of 25-hydroxyvitamin D
Total Cholesterol	8 weeks	serum level of total cholesterol
HDL Cholesterol	8 weeks	serum level of HDL Cholesterol

Secondary

Measure	Time frame	Description
Calcium and Phosphorus	8 weeks	serum level of Calcium and Phosphorus
PTH	8 weeks	serum level of PTH

Countries

Jordan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026