Joint Effusion
Conditions
Brief summary
To study the diagnostic performance of infrared spectroscopy on fresh synovial fluids in early septic arthritis diagnosis in patients with acute joint effusion
Detailed description
Diagnosis of a joint effusion is frequently a medical emergency, especially when septic arthritis is suspected. Septic arthritis diagnosis relies on microscopic and bacteriological analysis of synovial fluid obtained by arthrocentesis. Direct microscopic examination can be made within 2 to 12 hours but it is negative in about 50 % of the cases. It is necessary to wait 72 hours to obtain the result of the culture and reasonably rule out the diagnosis of septic arthritis. A method of establishing an immediate etiological diagnosis could improve the care of patients with joint effusion that is a therapeutic emergency and justify a hospitalization and a parenteral antibiotic therapy.
Interventions
DEVICEInfrared spectroscopy
Infrared spectroscopy
Sponsors
Rennes University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients over 18 year old * patients with an acute arthritis defined by an evolution of less than 6 weeks * patients benefiting from joint fluid puncture for diagnostic purposes in the rheumatology hospitals participating in the study * patients who received information about the protocol and have not expressed opposition to participate
Exclusion criteria
* patients opposing the study * protected major (safeguard justice, trusteeship and guardianship) and persons deprived of liberty
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnosis of the cause of joint effusion | Up to 7 days (time to perform Spectroscopy and collect laboratory results) | The final diagnosis of the cause of joint effusion is made by the clinician based on the clinical and laboratory data : septic arthritis or other causes of arthritis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of days of hospitalization | Up to 2 months (time to collect data on hospitalization duration and antibiotic therapy duration) | The clinician will be asked to state how a positive or a negative result of the diagnostic test under study would have affected his decision to hospitalize the patient |
| Total dose of antibiotics | Up to 2 months (time to collect data on hospitalization duration and antibiotic therapy duration) | The clinician will be asked to state how a positive or a negative result of the diagnostic test under study would have affected his decision to start antibiotic therapy |
Countries
France
Outcome results
None listed